List of the Top 13 Advanced Threat Protection (ATP) Software for Windows in 2025

To effectively combat ransomware, IT professionals must implement strategies that go beyond merely monitoring for threats. ThreatLocker offers a solution by minimizing attack surfaces through policy-driven endpoint security, shifting the focus from just blocking recognized threats to preventing anything that isn’t expressly permitted. By incorporating features like Ringfencing and other robust controls, organizations can bolster their Zero Trust framework and effectively thwart attacks that exploit existing resources. Explore the comprehensive suite of ThreatLocker’s Zero Trust endpoint security solutions, which includes Allowlisting, Ringfencing, Elevation Control, Storage Control, Network Access Control, Unified Audit, ThreatLocker Ops, Community, Configuration Manager, and Health Center, to enhance your cybersecurity posture today. This proactive approach not only safeguards your network but also empowers your team to maintain greater control over security protocols.

Trustifi delivers top-tier email security services designed to assist businesses of all sizes in effectively managing threat detection, ensuring compliance with regulations, and implementing data encryption. Its solutions can be easily integrated with popular email platforms such as Outlook and Gmail, as well as any other email server through a relay system. Among the features offered are Advanced Threat Protection, which includes malware and ransomware detection along with Business Email Compromise (BEC) attack prevention alerts, as well as Data Loss Prevention that adheres to strict compliance standards like HIPAA/HITECH, PII, GDPR, FSA, LGPD, and CCPA. Furthermore, Trustifi provides NSA-grade encryption to safeguard sensitive information, and only select Enterprise clients are granted access to customized branding and product white-labeling options. Additionally, personalized training sessions are available for teams to enhance their understanding of the system. Given the diverse encryption needs of organizations, Trustifi recognizes that there is no universal solution for email security, and thus frequently offers tailored solutions upon request, often at no additional cost. This commitment to customization ensures that each client's unique security requirements are effectively addressed.

An exceptionally groundbreaking platform. Unrivaled speed. Infinite scalability. Singularity™ delivers unmatched visibility, premium detection features, and autonomous response systems. Discover the power of AI-enhanced cybersecurity that encompasses the whole organization. The leading enterprises globally depend on the Singularity platform to detect, prevent, and manage cyber threats with astonishing rapidity, expansive reach, and improved accuracy across endpoints, cloud infrastructures, and identity oversight. SentinelOne provides cutting-edge security through this innovative platform, effectively protecting against malware, exploits, and scripts. Designed to meet industry security standards, the SentinelOne cloud-based solution offers high performance across diverse operating systems such as Windows, Mac, and Linux. With its ongoing updates, proactive threat hunting, and behavioral AI capabilities, the platform is adept at addressing any new threats, guaranteeing thorough protection. Additionally, its flexible design empowers organizations to remain ahead of cybercriminals in a continuously changing threat environment, making it an essential tool for modern cybersecurity strategies.

Trellix Endpoint Security (HX) facilitates swift and accurate forensic analyses across multiple endpoints. By adopting a holistic security strategy, you can effectively protect and reinforce your workforce across all devices. Trellix's Endpoint Security offerings utilize proactive threat intelligence and strong defense mechanisms at every stage of the attack lifecycle, thereby fortifying your organization's safety and resilience. In an age where threats are continuously evolving, it is vital to ensure the security of your endpoints is never compromised. Explore how our integrated suite of endpoint protection technologies provides you with actionable insights, machine learning features, and additional resources that enable ongoing threat monitoring and attack prevention. The core of endpoint security focuses on safeguarding data and workflows associated with each device connected to your network. Endpoint protection platforms (EPP) work by analyzing files as they enter the network, contributing to a safer digital space for all users. By prioritizing investment in cutting-edge security solutions, organizations can proactively defend against potential cyber threats, thereby significantly enhancing their overall security posture. Additionally, fostering a culture of security awareness among employees can further mitigate risks and ensure a collective commitment to safeguarding digital assets.

Symantec Endpoint Security presents a highly integrated and expansive platform for endpoint protection that is recognized globally. Whether utilized on-site, in a hybrid arrangement, or via the cloud, the cohesive Symantec framework protects a wide range of endpoint devices, from traditional computers to mobile gadgets, by utilizing artificial intelligence (AI) to bolster security decision-making processes. The efficient cloud management system simplifies the processes of protection, detection, and response against intricate threats targeting your endpoints. It is vital to sustain seamless business operations since compromised endpoints have the potential to significantly hinder productivity. By implementing cutting-edge strategies for preventing attacks and minimizing the attack surface, this solution delivers robust security throughout every phase of the attack lifecycle, addressing diverse threats including stealthy malware, credential theft, fileless attacks, and tactics that exploit existing systems. It is crucial to avert dire situations, as large-scale breaches pose a significant threat to Chief Information Security Officers (CISOs). The platform’s advanced attack analytics facilitate the effective identification and remediation of ongoing threats while also safeguarding against the theft of Active Directory credentials, thereby securing your organization’s environment. Furthermore, this all-encompassing strategy empowers organizations to maintain an advantage in an ever-changing threat landscape while continuously adapting to new challenges. In this dynamic environment, staying ahead of potential threats is not just beneficial, but essential for long-term success.

Protect your organization’s endpoints, confidential information, and users with ESET's extensive multilayered security solutions. The ESET PROTECT platform offers customized security features that are easy to oversee through a cloud-based management console. This approach improves cyber risk management while providing insight into your technological framework. By proactively addressing both established and emerging threats, you can more effectively safeguard your environment. Continuous updates and tailored notifications empower IT teams to promptly respond to any threats that may surface. Furthermore, intelligent predefined policies and automation help IT administrators save time while strengthening defenses against potential cyberattacks. Streamlining compliance with reporting requirements is more straightforward thanks to scheduled reports and a variety of customizable templates. It is vital to remain vigilant, as a user within your network might unwittingly open a malicious email containing a new form of ransomware. In addition, developers on their workstations may accidentally trigger false positives during software compilation, highlighting the necessity for a strong security framework. Therefore, embracing a proactive security approach is crucial for reducing risks related to both user conduct and software development efforts. This comprehensive strategy ensures that your organization remains resilient against ever-evolving cyber threats.

Work from anywhere, at any time, and using any device with ease. Experience the freedom of remote work through a cloud-based Windows desktop that guarantees a seamless working experience for your teams, while also providing high levels of security, affordability, and scalability essential for smooth business operations. The Virtual Cloud Desktops come fortified with Advanced Threat Protection in the Windows 2019 Edition, ensuring strong security measures are in place. With a user-friendly WorkDesk management system, maintaining a cohesive remote work environment is as simple as a push of a button. You can take advantage of a Pay-Per-Use model that eliminates upfront expenses, allowing you to pay solely for the hours you utilize. Customize your system configuration effortlessly with a click, enabling swift adjustments to your resources based on your needs. Built-in secure access features come with options that can be tailored to meet specific demands. Storing your data in the cloud guarantees that your information remains secure while also being accessible from any device, at any moment. Designed for user-friendliness, this system requires no manual input, which makes remote work smooth and straightforward for everyone involved. Furthermore, this setup significantly boosts productivity by allowing teams to concentrate on their tasks without the distraction of technical issues, ultimately fostering a more efficient work environment. As a result, remote work becomes not only feasible but also a highly effective way to collaborate and achieve goals.

Stay proactive against sophisticated threats like ransomware and state-sponsored attacks. Equip defenders with the tools necessary to effectively handle risks and refine their security strategies. Transition beyond standalone endpoint solutions to develop a more sophisticated security framework that is based on XDR and Zero Trust principles. Microsoft Defender for Endpoint offers exceptional protection for a wide array of platforms, including Windows, macOS, Linux, Android, iOS, and various network devices, allowing for rapid attack response, resource flexibility, and progressive defense mechanisms. By harnessing the power of cloud scalability and integrated AI, it taps into the most comprehensive threat intelligence available in the market. This all-inclusive solution aids in recognizing every endpoint and network device, such as routers, present in your operational environment. It includes features such as vulnerability management, endpoint protection, endpoint detection and response (EDR), mobile threat defense, and managed hunting, all seamlessly integrated into a single platform, thereby guaranteeing thorough security coverage. With this cohesive strategy, organizations are positioned to fortify their defenses while ensuring they maintain visibility over all their digital assets. Moreover, this integrated approach not only enhances security but also fosters a culture of continuous improvement in cybersecurity practices.

Juniper Advanced Threat Prevention (ATP) functions as the primary center for threat intelligence within your network setup. It offers a wide range of advanced security services that utilize artificial intelligence and machine learning techniques to detect attacks early and improve policy enforcement across the network. Available as a cloud-enabled service on an SRX Series Firewall or as a virtual appliance deployed locally, Juniper ATP is adept at identifying and mitigating both standard malware and zero-day vulnerabilities in files, IP traffic, and DNS queries. The solution thoroughly assesses risks from both encrypted and unencrypted network traffic, including that from IoT devices, and disseminates this vital intelligence throughout the network, effectively lowering your attack surface and curtailing the likelihood of security breaches. Furthermore, it automatically recognizes and mitigates known threats as well as zero-day vulnerabilities, bolstering overall security posture. The system also has the capability to spot and block threats hidden within encrypted traffic without the need for decryption, while identifying targeted attacks on your network involving high-risk users and devices, thus facilitating the automatic activation of your defense protocols. In essence, Juniper ATP significantly strengthens your network's defenses against the constantly changing landscape of cyber threats, ensuring a more secure operational environment.

Enhance your threat detection and IT security measures through sophisticated querying and remote response capabilities. Protect your organization from ransomware with robust file safeguarding, automated recovery options, and behavioral analytics specifically crafted to counteract ransomware and boot record attacks. Intercept X employs advanced deep learning technology, leveraging artificial intelligence to recognize both established and emerging malware without relying on traditional signatures. By obstructing the techniques and tools employed by attackers to distribute malware, steal credentials, and escape detection, you can effectively shield your systems. A dedicated team of threat hunters and response professionals proactively engages to eliminate even the most sophisticated threats on your behalf. Furthermore, the implementation of active adversary mitigation not only prevents persistence within systems but also protects against credential theft and improves the identification of harmful traffic, thereby fortifying your overall security framework. With these comprehensive features, organizations can markedly enhance their defense against the continuously evolving landscape of cyber threats, ensuring greater peace of mind and operational integrity.

iPrism Web Security integrates detailed content filtering with methods for threat detection and mitigation, delivering robust defense against Advanced Persistent Threats, including botnets and viruses. Its user-friendly design allows for a "set it and forget it" functionality, operating as a self-sufficient system that offers advanced threat protection and policy enforcement with minimal maintenance required. Additionally, the extensive reporting capabilities simplify network management for users. By utilizing a distinctive mix of iGuard's automated intelligence along with human analysis, iPrism effectively blocks malware, such as Crypto-Locker, and prevents access to inappropriate websites. This innovative strategy not only enhances user productivity by minimizing latency and reducing false negatives but also guarantees that you benefit from the latest and most effective web protection around the clock, backed by exceptional customer support. Furthermore, iPrism’s proactive measures ensure that your network remains secure against evolving threats.

As cyber threats evolve in complexity and become increasingly challenging to detect, organizations find themselves needing to adopt more extensive security measures, which often disrupt user workflows. In this scenario, SandBlast Network distinguishes itself by delivering outstanding protection against zero-day vulnerabilities while simplifying security management and facilitating smooth business operations. This leading-edge solution alleviates administrative tasks, allowing productivity to flourish. By harnessing cutting-edge threat intelligence and AI technologies, it successfully neutralizes unfamiliar cyber threats before they cause harm. Users benefit from an intuitive setup process that includes one-click installation and pre-configured profiles designed to cater to various business needs. SandBlast Network prioritizes prevention, ensuring that user experience remains intact without sacrificing security. It acknowledges that human behavior can be a significant vulnerability, implementing proactive user safeguards to prevent potential threats from impacting individuals, whether they are browsing the internet or managing emails. Additionally, it taps into real-time threat intelligence sourced from an extensive network of global sensors, continually refining its defenses against new risks. This holistic approach not only fortifies organizational security but also guarantees that operational efficiency is preserved, allowing businesses to thrive in a secure environment. Ultimately, SandBlast Network empowers organizations to navigate the digital landscape confidently, knowing they are protected against a myriad of evolving cyber threats.

Unlike the earlier, simpler viruses that were few in number, traditional antivirus solutions relied on a database of signatures to effectively protect systems. However, the current malware landscape has drastically changed, employing sophisticated techniques that often exploit existing vulnerabilities. When these weaknesses in trusted applications are taken advantage of, they can result in unpredictable behavior, which attackers exploit to compromise computer security. This tactic of exploiting an undisclosed software vulnerability is known as a zero-day or 0-day attack, and before the implementation of sandboxing, there were limited effective preventive measures available. A malware sandbox acts as a safeguard by confining an application’s functions, such as those involved in processing a Word document, to a controlled environment. This isolation enables the sandbox to observe the dynamic behaviors and interactions of applications in a simulated user environment, helping to unveil any potential malicious activities. This innovative technology plays a crucial role in combating advanced threats and has become a vital component of a more comprehensive cybersecurity strategy. As technology continues to evolve, the importance of such protective measures in thwarting increasingly sophisticated attacks cannot be overstated.