List of the Top 5 HPC Software for Amazon EKS in 2025

Amazon's EC2 P4d instances are designed to deliver outstanding performance for machine learning training and high-performance computing applications within the cloud. Featuring NVIDIA A100 Tensor Core GPUs, these instances are capable of achieving impressive throughput while offering low-latency networking that supports a remarkable 400 Gbps instance networking speed. P4d instances serve as a budget-friendly option, allowing businesses to realize savings of up to 60% during the training of machine learning models and providing an average performance boost of 2.5 times for deep learning tasks when compared to previous P3 and P3dn versions. They are often utilized in large configurations known as Amazon EC2 UltraClusters, which effectively combine high-performance computing, networking, and storage capabilities. This architecture enables users to scale their operations from just a few to thousands of NVIDIA A100 GPUs, tailored to their particular project needs. A diverse group of users, such as researchers, data scientists, and software developers, can take advantage of P4d instances for a variety of machine learning tasks including natural language processing, object detection and classification, as well as recommendation systems. Additionally, these instances are well-suited for high-performance computing endeavors like drug discovery and intricate data analyses. The blend of remarkable performance and the ability to scale effectively makes P4d instances an exceptional option for addressing a wide range of computational challenges, ensuring that users can meet their evolving needs efficiently.

Amazon S3 Express One Zone is engineered for optimal performance within a single Availability Zone, specifically designed to deliver swift access to frequently accessed data and accommodate latency-sensitive applications with response times in the single-digit milliseconds range. This specialized storage class accelerates data retrieval speeds by up to tenfold and can cut request costs by as much as 50% when compared to the standard S3 tier. By enabling users to select a specific AWS Availability Zone for their data, S3 Express One Zone fosters the co-location of storage and compute resources, which can enhance performance and lower computing costs, thereby expediting workload execution. The data is structured in a unique S3 directory bucket format, capable of managing hundreds of thousands of requests per second efficiently. Furthermore, S3 Express One Zone integrates effortlessly with a variety of services, such as Amazon SageMaker Model Training, Amazon Athena, Amazon EMR, and AWS Glue Data Catalog, thereby streamlining machine learning and analytical workflows. This innovative storage solution not only satisfies the requirements of high-performance applications but also improves operational efficiency by simplifying data access and processing, making it a valuable asset for businesses aiming to optimize their cloud infrastructure. Additionally, its ability to provide quick scalability further enhances its appeal to companies with fluctuating data needs.

Amazon's EC2 P5 instances, equipped with NVIDIA H100 Tensor Core GPUs, alongside the P5e and P5en variants utilizing NVIDIA H200 Tensor Core GPUs, deliver exceptional capabilities for deep learning and high-performance computing endeavors. These instances can boost your solution development speed by up to four times compared to earlier GPU-based EC2 offerings, while also reducing the costs linked to machine learning model training by as much as 40%. This remarkable efficiency accelerates solution iterations, leading to a quicker time-to-market. Specifically designed for training and deploying cutting-edge large language models and diffusion models, the P5 series is indispensable for tackling the most complex generative AI challenges. Such applications span a diverse array of functionalities, including question-answering, code generation, image and video synthesis, and speech recognition. In addition, these instances are adept at scaling to accommodate demanding high-performance computing tasks, such as those found in pharmaceutical research and discovery, thereby broadening their applicability across numerous industries. Ultimately, Amazon EC2's P5 series not only amplifies computational capabilities but also fosters innovation across a variety of sectors, enabling businesses to stay ahead of the curve in technological advancements. The integration of these advanced instances can transform how organizations approach their most critical computational challenges.

Amazon EC2 UltraClusters provide the ability to scale up to thousands of GPUs or specialized machine learning accelerators such as AWS Trainium, offering immediate access to performance comparable to supercomputing. They democratize advanced computing for developers working in machine learning, generative AI, and high-performance computing through a straightforward pay-as-you-go model, which removes the burden of setup and maintenance costs. These UltraClusters consist of numerous accelerated EC2 instances that are optimally organized within a particular AWS Availability Zone and interconnected through Elastic Fabric Adapter (EFA) networking over a petabit-scale nonblocking network. This cutting-edge arrangement ensures enhanced networking performance and includes access to Amazon FSx for Lustre, a fully managed shared storage system that is based on a high-performance parallel file system, enabling the efficient processing of large datasets with latencies in the sub-millisecond range. Additionally, EC2 UltraClusters support greater scalability for distributed machine learning training and seamlessly integrated high-performance computing tasks, thereby significantly reducing the time required for training. This infrastructure not only meets but exceeds the requirements for the most demanding computational applications, making it an essential tool for modern developers. With such capabilities, organizations can tackle complex challenges with confidence and efficiency.

Amazon EC2 G4 instances are meticulously engineered to boost the efficiency of machine learning inference and applications that demand superior graphics performance. Users have the option to choose between NVIDIA T4 GPUs (G4dn) and AMD Radeon Pro V520 GPUs (G4ad) based on their specific needs. The G4dn instances merge NVIDIA T4 GPUs with custom Intel Cascade Lake CPUs, providing an ideal combination of processing power, memory, and networking capacity. These instances excel in various applications, including the deployment of machine learning models, video transcoding, game streaming, and graphic rendering. Conversely, the G4ad instances, which feature AMD Radeon Pro V520 GPUs and 2nd-generation AMD EPYC processors, present a cost-effective solution for managing graphics-heavy tasks. Both types of instances take advantage of Amazon Elastic Inference, enabling users to incorporate affordable GPU-enhanced inference acceleration to Amazon EC2, which helps reduce expenses tied to deep learning inference. Available in multiple sizes, these instances are tailored to accommodate varying performance needs and they integrate smoothly with a multitude of AWS services, such as Amazon SageMaker, Amazon ECS, and Amazon EKS. Furthermore, this adaptability positions G4 instances as a highly appealing option for businesses aiming to harness the power of cloud-based machine learning and graphics processing workflows, thereby facilitating innovation and efficiency.