Evo 2 Integrations

GitHub remains the foremost platform for developers around the world, celebrated for its robust security, impressive scalability, and strong community engagement. By becoming part of the vast network of millions of developers and organizations, you can play a role in creating the software that propels society forward. Engage and collaborate with some of the most innovative communities while taking advantage of our exceptional tools, support, and services. If you are managing multiple contributors, consider utilizing our complimentary GitHub Team for Open Source feature. Furthermore, GitHub Sponsors is designed to help finance your initiatives and projects effectively. We are excited to bring back The Pack, a program that offers students and educators free access to top-notch developer tools throughout the academic year and beyond. In addition, if you are affiliated with a recognized nonprofit, association, or a 501(c)(3) organization, we provide a discounted Organization account to help further your mission. Through these initiatives, GitHub continues to empower a diverse range of users in their software development endeavors, fostering a more inclusive tech community. With ongoing support and resources, GitHub is dedicated to enhancing the development experience for everyone involved.

Hugging Face is an AI-driven platform designed for developers, researchers, and businesses to collaborate on machine learning projects. The platform hosts an extensive collection of pre-trained models, datasets, and tools that can be used to solve complex problems in natural language processing, computer vision, and more. With open-source projects like Transformers and Diffusers, Hugging Face provides resources that help accelerate AI development and make machine learning accessible to a broader audience. The platform’s community-driven approach fosters innovation and continuous improvement in AI applications.

Evo Designer, an innovative instrument developed by the Arc Institute, leverages the capabilities of the Evo 2 genomic foundation model to assist in both the creation and examination of DNA sequences. By allowing users to input nucleotide sequences or choose particular organisms, the platform generates tailored DNA sequences that meet specific research requirements. Moreover, it provides comprehensive annotations for coding regions and enables 3D visualizations of prokaryotic protein structures through ESMFold, thereby deepening users' comprehension of protein architecture. Additionally, Evo Designer assesses the complexity of sequences by calculating perplexity and per-nucleotide entropy, offering researchers insights into the variability of their data. Central to this tool is the Evo 2 model, which has been trained on a vast dataset exceeding 9 trillion nucleotides from a diverse range of prokaryotic and eukaryotic genomes. Harnessing an advanced deep learning framework, this model accurately represents biological sequences at a single-nucleotide level and can accommodate a context window of up to 1 million tokens, ensuring meticulous sequence analysis. The diverse features offered by Evo Designer significantly enhance genetic research, making it a crucial asset for scientists in the field. As a result, the tool not only streamlines the process of DNA sequence analysis but also fosters deeper insights into genetic structures and their functions.

BioNeMo is a cloud-based platform designed for drug discovery that harnesses artificial intelligence and employs NVIDIA NeMo Megatron to enable the training and deployment of large biomolecular transformer models at an impressive scale. This service provides users with access to pre-trained large language models (LLMs) and supports multiple file formats pertinent to proteins, DNA, RNA, and chemistry, while also offering data loaders for SMILES to represent molecular structures and FASTA for sequences of amino acids and nucleotides. In addition, users have the flexibility to download the BioNeMo framework for local execution on their own machines. Among the notable models available are ESM-1, which is based on Meta AI’s state-of-the-art ESM-1b, and ProtT5, both fine-tuned transformer models aimed at protein language tasks that assist in generating learned embeddings for predicting protein structures and properties. Furthermore, the platform will incorporate OpenFold, an innovative deep learning model specifically focused on forecasting the 3D structures of new protein sequences, which significantly boosts its capabilities in biomolecular exploration. Overall, this extensive array of tools establishes BioNeMo as an invaluable asset for researchers navigating the complexities of drug discovery in modern science. As such, BioNeMo not only streamlines research processes but also empowers scientists to make significant advancements in the field.