List of the Top 8 Application Control Software for Mac in 2025

Airlock Digital provides application control and allowlisting, used by organizations worldwide to protect against ransomware, malware and other cyber threats. Our deny by default solution enables customers to run only the applications and files they trust, with all others blocked from executing. This approach minimizes attack surfaces and helps organizations align their cybersecurity strategies with government frameworks and standards. By securing endpoints running legacy and new versions of Windows, macOS and Linux, we extend protection across IT and operational technology environments. Airlock Digital delivers endpoint protection to financial services, government, healthcare, manufacturing and other industry organizations of all sizes.

ManageEngine's Endpoint Central, which was previously known as Desktop Central, serves as a comprehensive Unified Endpoint Management Solution that oversees enterprise mobility management. This solution encompasses all aspects of mobile app and device management, in addition to client management for various endpoints, including mobile devices, laptops, tablets, servers, and other computing machines. With ManageEngine Endpoint Central, users can streamline and automate numerous desktop management activities, such as software installation, patching, IT asset management, imaging, and operating system deployment, thereby enhancing operational efficiency across the organization. This tool is particularly beneficial for IT departments looking to maintain control over their diverse technology environments.

ThreatLocker® empowers organizations—from businesses and government agencies to academic institutions—with the ability to control exactly which applications are allowed to run in their environments. Built on a Zero Trust foundation, our suite of powerful cybersecurity tools puts control back in your hands. We believe in a future where every organization can operate securely and independently, free from the disruption of cyberattacks. That’s why our team of seasoned cybersecurity experts designed ThreatLocker: to give you the tools to stop threats before they start. With decades of experience developing cutting-edge security solutions, including email and content protection, ThreatLocker is our most advanced and comprehensive platform yet. It’s built to help you reduce risk, simplify your stack, and take control. Learn more at ThreatLocker.com.

Heimdal® Endpoint Detection and Response is our exclusive multi-faceted service that offers exceptional capabilities for prevention, threat hunting, and remediation. This service integrates the most cutting-edge threat-hunting technologies available, including Heimdal Next-Gen Antivirus, Heimdal Privileged Access Management, Heimdal Application Control, Heimdal Ransomware Encryption Protection, Heimdal Patch & Asset Management, and Heimdal Threat Prevention. With six modules functioning together harmoniously under a single platform and agent, Heimdal Endpoint Detection and Response provides comprehensive cybersecurity layers necessary for safeguarding your organization against both familiar and unfamiliar online and internal threats. Our advanced product enables rapid and precise responses to complex malware, ensuring that your digital assets are protected while also maintaining your organization's reputation. By consolidating these capabilities, we deliver an efficient solution that addresses the evolving challenges of cybersecurity effectively.

A Unified Endpoint Management system designed to be modular, scalable, and cost-effective, catering to IT administration, security, and workflow automation needs. Users can operate all modules from a single interface linked to one database. Currently, there are 18 modules to select from, with the flexibility to incorporate additional ones as required for tasks such as OS installation and cloning, patch management, vulnerability management, and mobile device management. This approach ensures that organizations can tailor their endpoint management solutions to fit their specific requirements efficiently.

Privilege Manager stands out as a comprehensive solution for endpoint privilege elevation and control, functioning with the speed of cloud technology. By eliminating administrative rights from local devices and enforcing policy-driven controls over applications, it effectively mitigates the risk of malware exploitation. Additionally, Privilege Manager not only blocks malware attacks but also ensures that end users experience no disruption, thereby maintaining productivity levels. Available in both on-premises and cloud formats, Privilege Manager caters to the needs of rapidly expanding businesses and teams, allowing them to efficiently oversee hundreds to thousands of machines. Moreover, it simplifies the management of endpoints for executives and auditors alike, boasting features such as embedded application control, real-time threat intelligence, and detailed actionable reports that enhance overall security management. With these capabilities, organizations can achieve a robust security posture while empowering their workforce.

PC Matic Pro utilizes application whitelisting as a crucial layer of defense that strengthens current endpoint security protocols. This zero trust methodology successfully deters hacking attempts and various cyber threats, effectively blocking the execution of malware, ransomware, and malicious scripts to provide strong protection for business data, users, and networks through its dedicated whitelist cybersecurity framework. Representing a noteworthy leap in the cybersecurity realm, PC Matic Pro exemplifies an essential shift toward holistic prevention strategies. In light of the escalating threats aimed at critical infrastructure, diverse industries, and government agencies, adopting such a proactive approach is vital. The software includes a patented default-deny security mechanism at the device level, which stops all unauthorized executions without complicating the workflow for IT teams. Unlike conventional security solutions, there is no requirement for customer infections to improve the whitelisting process. Additionally, organizations can implement local overrides after prevention with a focus on accuracy, allowing for a secure environment that mitigates the need for reactive measures against existing threats. This approach not only fortifies defenses but also adapts effortlessly to the constantly changing landscape of cyber risks, ensuring long-term resilience. Overall, PC Matic Pro stands out as an indispensable tool for organizations seeking to elevate their cybersecurity posture.

Ivanti is a comprehensive IT management platform that helps organizations automate, secure, and optimize their technology environments. With Unified Endpoint Management, Ivanti provides centralized, user-friendly control over all endpoints, enabling IT teams to manage devices seamlessly regardless of location. Their Enterprise Service Management suite enhances operational insights, streamlining workflows and reducing IT service disruptions for a better employee experience. Ivanti also delivers robust network security and exposure management solutions, helping businesses identify vulnerabilities and prioritize remediation efforts to strengthen cybersecurity defenses. Trusted by over 34,000 customers worldwide, including major brands such as Foxwoods Casino and Conair, Ivanti supports secure work-from-anywhere strategies that boost productivity and flexibility. The company regularly publishes research reports on key topics like cybersecurity posture, digital employee experience, and workplace technology trends. Ivanti’s customer advocacy initiatives demonstrate a commitment to partnership and success, with dedicated support teams ensuring clients achieve their goals. Their solutions are scalable and adaptable, fitting the needs of organizations of all sizes. Ivanti empowers IT leaders to turn visibility into actionable value, driving efficient and secure operations. Ultimately, Ivanti’s integrated approach helps businesses navigate the evolving digital landscape with confidence.