List of the Top 5 Endpoint Protection Software for ConnectWise Automate in 2026

Guardz is the unified cybersecurity platform built for MSPs. We consolidate the essential security controls, including identities, endpoints, email, awareness, and more, into one AI-native framework designed for operational efficiency. With an identity-centric approach, an elite threat hunting team, and 24/7 AI + human-led MDR, Guardz transforms cybersecurity from reactive defense into proactive protection.

This EDR solution is designed to reveal the untapped capabilities of your network. Utilizing ESET's comprehensive Endpoint Protection Platform, this tool effectively identifies and manages endpoint security issues. It channels all relevant data to ESET Enterprise Inspector, which processes vast amounts of real-time information from endpoints. With impressive speed, it can pinpoint and resolve any security vulnerabilities within the network. ESET Enterprise Inspector features a distinctive reputation-based detection approach that remains unobtrusive for security personnel. For enhanced customization, users can easily modify all rules through XML. You also have the flexibility to develop new rules tailored to the specific requirements of your organization, including seamless integrations with SIEM systems. ESET's endpoint detection and response tool simplifies the management of false positives, allowing you to fine-tune detection sensitivity across various user groups or computer categories. By combining criteria such as file name, path, hash, command line, and signer, you can precisely adjust the conditions under which alerts are triggered, ensuring a tailored security approach. This level of customization empowers organizations to enhance their overall security posture effectively.

Acronis Cyber Protect offers reassurance by ensuring that your business is shielded against threats such as zero-day malware and ransomware, while also providing backup solutions and forensic analysis. With the rapid evolution of cyber threats, relying on basic data backup and cybersecurity measures is no longer sufficient to keep them at bay. Acronis provides comprehensive cyber protection that integrates cybersecurity, data backup, disaster recovery, and additional features to maintain the security of your essential data and systems. Many businesses find themselves relying on a convoluted mix of tools to protect against data loss and cyber threats, but this fragmented approach can create management challenges and leave vulnerabilities. In contrast, Acronis’ unified cyber protection offerings effectively secure complete workloads with improved efficiency and reduced complexity, allowing your team to prioritize protection and strategic initiatives instead of managing disparate solutions. Easily safeguard entire workloads without complications, as getting started with Acronis' cyber protection solutions is both straightforward and seamless. You can provision numerous systems with just a single click and oversee everything—from backup policies to vulnerability assessments and patch management—through a unified interface, streamlining your cybersecurity efforts.

OpenText Core Endpoint Protection is a modern, cloud-powered security solution built to defend organizations from escalating threats such as ransomware, phishing, and zero-day exploits. It leverages advanced machine learning and the extensive OpenText Threat Intelligence network to detect malicious behavior as it happens and automatically intervene. The platform continuously analyzes processes, network activity, and file behaviors to identify abnormalities that signal an attack. Administrators gain centralized, cloud-based control over every endpoint, enabling policy enforcement, monitoring, and incident response from anywhere. Simple policy templates and tight RMM integrations reduce complexity, making deployment and management fast and efficient. When suspicious activity is detected, teams can isolate devices instantly and visualize the event chain to support detailed investigations. For organizations needing expanded capabilities, OpenText Core Endpoint Protection works in tandem with OpenText Core EDR to deliver deeper telemetry, root-cause analysis, and automated response workflows. End users benefit from quiet, unobtrusive protection, while IT leaders gain assurance that systems remain secure without performance drops. The platform supports compliance readiness by enforcing consistent security standards across distributed environments. Overall, OpenText Core Endpoint Protection helps businesses minimize downtime, reduce risk, and maintain resilience in the face of rapidly evolving cyber threats.

VIPRE Endpoint Protection delivers a strong defense against the increasingly advanced malware threats of today, ensuring top-tier security without the added complications often associated with other endpoint solutions. It is engineered to maintain a low total cost of ownership while integrating cutting-edge machine learning, real-time behavioral analysis, and a worldwide threat intelligence network for proactive security measures. This cloud-based solution harmonizes a contemporary, efficient endpoint defense with time-saving features, allowing your organization to operate seamlessly. VIPRE's protection spans file, application, and network levels, ensuring thorough malware defense across all potential attack vectors. Additionally, it empowers organizations to implement detailed internet usage policies with specific safeguards that fulfill employers' responsibilities for duty of care. With dynamic, real-time dashboards, users gain an intuitive and comprehensive overview of their endpoint environment, simplifying the process of monitoring security status and responding as necessary. By choosing VIPRE Endpoint Protection, organizations can achieve enhanced security with reduced complexity and increased efficiency. Whether you need a core next-generation antivirus solution, a full endpoint detection and response (EDR) option, or a combined EDR and managed detection and response (MDR) package, VIPRE offers tailored solutions to meet your needs. Each option is designed to ensure your organization's security while minimizing disruption to your daily operations.