List of the Top 4 Endpoint Protection Software for ConnectWise ScreenConnect in 2025

NinjaOne streamlines the most challenging aspects of IT management, serving over 20,000 IT teams with enhanced capabilities. By delivering in-depth insights into endpoints, strong security protocols, and a unified control system, NinjaOne increases operational efficiency, protects sensitive information, and reduces IT costs. This all-encompassing platform provides a diverse set of tools for managing and securing endpoints, such as patch management, mobile device supervision, software deployment, remote assistance, backup solutions, and additional features, all made possible through its wide-ranging IT and security integrations. With its ability to adapt to various IT environments and needs, NinjaOne stands out as a vital resource for modern IT teams.

To effectively combat ransomware, IT professionals must implement strategies that go beyond merely monitoring for threats. ThreatLocker offers a solution by minimizing attack surfaces through policy-driven endpoint security, shifting the focus from just blocking recognized threats to preventing anything that isn’t expressly permitted. By incorporating features like Ringfencing and other robust controls, organizations can bolster their Zero Trust framework and effectively thwart attacks that exploit existing resources. Explore the comprehensive suite of ThreatLocker’s Zero Trust endpoint security solutions, which includes Allowlisting, Ringfencing, Elevation Control, Storage Control, Network Access Control, Unified Audit, ThreatLocker Ops, Community, Configuration Manager, and Health Center, to enhance your cybersecurity posture today. This proactive approach not only safeguards your network but also empowers your team to maintain greater control over security protocols.

Syncro serves as a comprehensive business platform designed specifically for managing a successful managed service provider (MSP). Experience the convenience of PSA, RMM, and remote access all bundled into one cost-effective solution. Additionally, you can enhance your productivity even further with seamless integrations to over 50 MSP and business applications that you already utilize. The pricing structure of Syncro is straightforward, offering a single flat fee that covers all PSA, RMM, and remote access functionalities, allowing for unlimited endpoints with no binding contracts or minimum requirements. This simplicity makes it easier for MSPs to budget and plan their services effectively.

Acronis Cyber Protect offers reassurance by ensuring that your business is shielded against threats such as zero-day malware and ransomware, while also providing backup solutions and forensic analysis. With the rapid evolution of cyber threats, relying on basic data backup and cybersecurity measures is no longer sufficient to keep them at bay. Acronis provides comprehensive cyber protection that integrates cybersecurity, data backup, disaster recovery, and additional features to maintain the security of your essential data and systems. Many businesses find themselves relying on a convoluted mix of tools to protect against data loss and cyber threats, but this fragmented approach can create management challenges and leave vulnerabilities. In contrast, Acronis’ unified cyber protection offerings effectively secure complete workloads with improved efficiency and reduced complexity, allowing your team to prioritize protection and strategic initiatives instead of managing disparate solutions. Easily safeguard entire workloads without complications, as getting started with Acronis' cyber protection solutions is both straightforward and seamless. You can provision numerous systems with just a single click and oversee everything—from backup policies to vulnerability assessments and patch management—through a unified interface, streamlining your cybersecurity efforts.