List of the Top 4 Endpoint Protection Software for ConnectWise ScreenConnect in 2026

ThreatLocker is a Zero Trust platform designed to prevent cyber threats by ensuring only trusted applications and processes are allowed to operate. It eliminates persistent admin privileges, applies least privilege controls, and gives organizations granular control over how software runs. Through application allowlisting, ringfencing, and storage controls, it blocks ransomware, zero day attacks, and unauthorized behavior before anything can execute. Built for today’s IT and security teams, ThreatLocker delivers centralized control and real time visibility across endpoints, users, and applications. It reduces attack surface, limits lateral movement, and supports compliance with detailed logging and audit trails. With rapid deployment, a continuously maintained application library, and efficient approval processes, organizations can enhance security while lowering operational complexity and maintaining uptime.

NinjaOne bolsters endpoint security by implementing monitoring, patch management, and software controls. It utilizes automated notifications to detect unusual activities or unapproved applications. Consistent patch updates safeguard devices against potential vulnerabilities. Technicians can employ remote commands for immediate threat remediation. Additionally, backup capabilities offer further protection against ransomware attacks. Comprehensive reporting offers valuable insights into the security status of endpoints. With NinjaOne, endpoints are maintained in a secure and compliant state.

Syncro serves as a comprehensive business platform designed specifically for managing a successful managed service provider (MSP). Experience the convenience of PSA, RMM, and remote access all bundled into one cost-effective solution. Additionally, you can enhance your productivity even further with seamless integrations to over 50 MSP and business applications that you already utilize. The pricing structure of Syncro is straightforward, offering a single flat fee that covers all PSA, RMM, and remote access functionalities, allowing for unlimited endpoints with no binding contracts or minimum requirements. This simplicity makes it easier for MSPs to budget and plan their services effectively.

Acronis Cyber Protect offers reassurance by ensuring that your business is shielded against threats such as zero-day malware and ransomware, while also providing backup solutions and forensic analysis. With the rapid evolution of cyber threats, relying on basic data backup and cybersecurity measures is no longer sufficient to keep them at bay. Acronis provides comprehensive cyber protection that integrates cybersecurity, data backup, disaster recovery, and additional features to maintain the security of your essential data and systems. Many businesses find themselves relying on a convoluted mix of tools to protect against data loss and cyber threats, but this fragmented approach can create management challenges and leave vulnerabilities. In contrast, Acronis’ unified cyber protection offerings effectively secure complete workloads with improved efficiency and reduced complexity, allowing your team to prioritize protection and strategic initiatives instead of managing disparate solutions. Easily safeguard entire workloads without complications, as getting started with Acronis' cyber protection solutions is both straightforward and seamless. You can provision numerous systems with just a single click and oversee everything—from backup policies to vulnerability assessments and patch management—through a unified interface, streamlining your cybersecurity efforts.