List of the Top 12 Secure Email Gateway Software for Microsoft 365 in 2025

NeoCertified protects confidential data through our secure email application, which operates seamlessly on our adaptable Cloud-based platform. It is accessible via any web browser and integrates with Microsoft Office 365/Outlook and Gmail, while also offering dedicated mobile applications for both iPhone and Android devices. Since our inception in 2002, we have been delivering secure mail solutions that comply with federal standards, enabling organizations to send and receive secure emails from any web browser or mobile platform. Our service is compatible with all email providers, ensuring that businesses enjoy the flexibility and robust security they require for their communications. Additionally, our commitment to constant innovation guarantees that we meet the evolving needs of our clients in an increasingly digital world.

N-able Mail Assure is a cloud-based solution for email security that delivers sophisticated protection against threats for both incoming and outgoing emails, utilizing collective threat intelligence, a comprehensive email archive, and round-the-clock email continuity services. The platform features multi-tenant web interfaces equipped with preset configurations, detailed reporting, and visual tools that enhance oversight and management of all email transactions. This innovative system employs proprietary technology that analyzes extensive email data to enhance its Intelligent Protection and Filtering engine. By incorporating real-time threat pattern detection and leveraging a diverse array of filtering technologies, N-able Mail Assure effectively safeguards users from spam, viruses, phishing attempts, impersonation, malware, and various other email-related dangers. Additionally, its seamless integration and user-friendly interface ensure that organizations can maintain robust email security with minimal effort.

Boost your efficiency with a professional-grade email and calendar solution designed for businesses. Exchange allows for seamless collaboration on crucial documents while providing an organized inbox that prioritizes important messages and adapts to your personal work style, enabling you to handle tasks with greater effectiveness. Enjoy a tailored inbox equipped with valuable features, alongside a more organized approach to managing and responding to emails. The enhanced search capabilities yield faster and more thorough results, and the integration of Add-ins presents robust customization options that connect you to modern services and internal business tools. Moreover, improve your scheduling experience with an advanced calendar system that goes beyond basic appointment management by automatically extracting information from emails, such as flight confirmations and hotel reservations, while also suggesting venues based on your geographical position. Microsoft Exchange Online serves as a reliable and secure hosted email solution for businesses, prioritizing the safeguarding of your data with sophisticated security protocols. When these powerful tools are combined, they create a streamlined workflow that not only enhances productivity but also inspires your team to think more creatively and collaborate more effectively. This innovative approach to communication and scheduling can significantly transform how your organization operates.

Strengthening the protection of your email accounts is vital, as email continues to be the main conduit for various threats. It is important to expand your security strategies to detect dangerous threats proactively and to effectively respond to and manage emerging risks as they occur. Understanding the malicious strategies that can target your organization is crucial for prevention. By identifying the specific vulnerabilities your business faces and categorizing the threats, you can gain a clearer picture of which areas are most at risk of an attack. Employing AI-driven threat detection allows multiple systems to simultaneously scrutinize various elements of incoming emails. The data collected from these analyses ensures accurate threat identification, evaluates potential business risks, and aids in formulating appropriate response plans. Cyber threats can come from numerous sources, such as phishing attacks, business email compromises, malware infections, and ransomware invasions. Safeguard your organization against all these dangers by leveraging advanced threat intelligence, which empowers you to act swiftly against any emerging risks. Given the constant evolution of cyber threats, it is essential to stay one step ahead of potential attackers by adopting robust and comprehensive security solutions that evolve alongside the threat landscape. Additionally, regular training and awareness for employees can significantly bolster your defenses against these risks.

MDaemon Technologies has created the email threat detection technology utilized by Security Gateway. For over two decades, this trailblazer in the email industry has been safeguarding email servers from various dangers like viruses, spam, and phishing. Organizations rely on their expertise to maintain the security of their email exchanges. Their protection extends to all email platforms, such as Microsoft Exchange and Office 365, among others. With a dedicated team of email security experts, Security Gateway simplifies the management of your organization’s email security needs. Utilizing the latest advancements in email threat detection technology and policy enforcement tools, Security Gateway ensures that legitimate emails are efficiently delivered to and from your users. Additionally, the cloud service offered by Security Gateway is straightforward to implement, allowing you to concentrate on other vital responsibilities. To learn more about the functionalities of Security Gateway, be sure to check out this informative video.

Protect the integrity of Microsoft Office 365, Google G Suite, and in-house email systems by deploying the industry's most effective email security solutions. Safeguard users from various threats, including spear phishing, credential compromise, and ransomware, by implementing Email Threat Isolation techniques. Address common email vulnerabilities such as spear phishing, ransomware, business email compromise, and spam with strong protective measures. Thwart spear phishing attempts through a layered defense system that includes threat isolation, spam filtering, advanced analytics, and user training initiatives. Shield against the latest ransomware threats by utilizing sophisticated content defense methods, sandboxing, and link protection technologies designed to detect new and hidden threats, including zero-day exploits. Counteract business email compromise by using impersonation safeguards, enforcing sender authentication, and applying brand protection tactics. Improve your brand's reputation and reduce risks by automating the enforcement of sender authentication methods like DMARC, DKIM, and SPF with Symantec Email Fraud Protection, which effectively tackles the challenges associated with email security. By adopting these comprehensive strategies, organizations not only protect their communications but also cultivate a security-conscious culture among their users, ultimately enhancing overall organizational resilience against email-based threats. Investing in these solutions is crucial for maintaining secure and trustworthy communication channels.

Efficiently categorize deceptive emails while proactively detecting and isolating questionable URLs. Utilizing big data analytics enables precise classification of mass email communications. This comprehensive solution integrates seamlessly with both Google Workspace and Microsoft 365. Spambrella's Email Security and User Awareness Training technology is trusted by numerous leading security-focused organizations worldwide, spanning various industries and regions. By partnering with Spambrella, you can consolidate your email security strategies and user training initiatives on an international scale. Acting as your dedicated email security team, Spambrella ensures a smooth transition while possessing the technical know-how of other major providers like Symantec.cloud, Mimecast, and MxLogic. To safeguard your email users from potential threats, reach out today to arrange a demonstration with our cybersecurity specialists and enhance your email protection strategy.

LuxSci is dedicated to ensuring the safety of personal information while effectively safeguarding global communications. The company focuses on delivering web and email communication services that adhere to HIPAA regulations. LuxSci develops highly secure and tailored enterprise-level environments and solutions, empowering businesses to meet their unique operational and security requirements effectively. Among the offerings are services like Secure Email, Web, and Forms, which are designed to enhance data protection and facilitate compliance. In addition, LuxSci continuously evolves its services to adapt to the changing landscape of digital security.

Make a wise investment today to bolster your defenses against email security threats by acquiring a robust email security solution tailored for small businesses at affordable rates. Cybercriminals are increasingly targeting high-level executives like CEOs and CFOs across various sectors, alongside crucial departments such as HR and Accounting. While Office 365 offers some level of protection, its capabilities are insufficient to effectively combat impersonations, email fraud, and phishing attacks. Relying solely on custom transport rules to block domains and guard against employee impersonations can leave significant gaps in security. PhishProtection stands out as it is compatible with all email servers, devices, and SMTP services, ensuring comprehensive protection regardless of your location or the email client you use. Whether you access your emails through your phone, Outlook, or other platforms, this solution offers top-notch security for both Android and iOS devices, making it a critical investment for safeguarding your business communications. In today’s evolving cyber landscape, prioritizing email security is not just smart; it's essential for every small business.

An additional layer of security has been established to block potential threats from infiltrating users within the network. This system is meticulously crafted to protect email communications, which are frequently the most vulnerable to cyberattacks. ESET proudly offers a true 64-bit product that accommodates clustering, ensuring that organizational speed remains efficient regardless of size. ESET Mail Security solutions incorporate a unique blend of anti-spam, anti-phishing, and host server protection, utilizing machine learning, comprehensive data analysis, and expert insights within an award-winning mail security framework. This advanced functionality significantly diminishes both unsolicited emails and targeted threats, allowing employees to focus on their tasks while maintaining uninterrupted business operations. Users are often confronted with phishing attempts that can carry additional malicious components, highlighting the necessity for a cohesive email security strategy. Depending on individual users to identify genuine emails can be an inefficient method, as they may quickly become overwhelmed by this responsibility. To ease this challenge, users are automatically alerted about spam emails that are quarantined, thereby improving their capability to manage their inboxes with greater efficiency. Furthermore, these notifications ensure that legitimate communications are not overlooked amidst the clutter of spam.

RevBits Email Security is an advanced solution designed to fill significant voids in the email security landscape. Utilizing innovative algorithms, including a cutting-edge page impersonation detection technique, it ensures an unparalleled level of email scrutiny. Each email is assigned a composite probabilistic score, providing valuable insights and fostering ongoing user education. Furthermore, this robust security tool enhances the overall email security framework by identifying and thwarting sophisticated malicious emails that may bypass existing protections. Ultimately, RevBits Email Security safeguards employee endpoints, which represent the final line of defense in email interactions. This proactive approach not only defends against threats but also empowers users with essential knowledge for better security practices.

Provides a strong defense against the intricate email threats that are common today, while also featuring extensive policy management along with thorough data security and compliance functionalities. Protecting your email infrastructure from various issues such as spam, malware, phishing schemes, business email compromise, account takeovers, and ransomware should be an essential priority. Trustwave's Secure Email Gateway (SEG) utilizes a multi-faceted intelligence and detection framework that performs a detailed assessment of incoming email traffic in real-time, guaranteeing that your users remain safe from cyber hazards. Additionally, it facilitates the smooth integration of email content workflows into your organizational practices and vigilantly supervises outgoing emails to prevent potential breaches involving sensitive data, trade secrets, confidential documents, and financial information. By implementing these security solutions in conjunction with the Secure Email Gateway, you significantly enhance your organization's protective measures and compliance protocols. This holistic strategy not only fortifies your email security but also optimizes your organizational workflows, ensuring that protection and efficiency go hand in hand. Consequently, your organization can confidently navigate the digital landscape while minimizing risks associated with email communication.