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What is ESMC?

ESMC marks the latest innovation in the ESM series of protein language models, advancing the understanding of representation learning in protein biology. By training on an enormous dataset of billions of evolutionary sequences, it effectively captures representations that provide insights into the mechanistic aspects of protein structure and function. Utilizing a transformer architecture, the model prioritizes sequences as its main input and is trained on a dataset that includes up to 6 billion proteins. ESMC is designed for a range of applications within protein science, including structure prediction, functional annotation, protein design, and the investigation of evolutionary relationships among proteins. Furthermore, it has the ability to generate new proteins from partial sequences, structures, or specific functional requirements, which allows researchers to explore novel possibilities in protein design and biological research. The model is readily accessible through the Biohub Platform, enabling users to interact with it via an API and the ESM Python package, which offers quickstart resources for installation, API key generation, and connection to the platform, thus ensuring a user-friendly experience. This ease of access not only promotes wider participation in protein research but also fosters collaborative efforts across the scientific community, ultimately driving further advancements in the field. With its capabilities, ESMC opens new doors for innovation and discovery in protein science.

What is NVIDIA BioNeMo?

BioNeMo is a cloud-based platform designed for drug discovery that harnesses artificial intelligence and employs NVIDIA NeMo Megatron to enable the training and deployment of large biomolecular transformer models at an impressive scale. This service provides users with access to pre-trained large language models (LLMs) and supports multiple file formats pertinent to proteins, DNA, RNA, and chemistry, while also offering data loaders for SMILES to represent molecular structures and FASTA for sequences of amino acids and nucleotides. In addition, users have the flexibility to download the BioNeMo framework for local execution on their own machines. Among the notable models available are ESM-1, which is based on Meta AI’s state-of-the-art ESM-1b, and ProtT5, both fine-tuned transformer models aimed at protein language tasks that assist in generating learned embeddings for predicting protein structures and properties. Furthermore, the platform will incorporate OpenFold, an innovative deep learning model specifically focused on forecasting the 3D structures of new protein sequences, which significantly boosts its capabilities in biomolecular exploration. Overall, this extensive array of tools establishes BioNeMo as an invaluable asset for researchers navigating the complexities of drug discovery in modern science. As such, BioNeMo not only streamlines research processes but also empowers scientists to make significant advancements in the field.

Media

Media

Integrations Supported

Biohub
Evo 2
NVIDIA AI Foundations
NVIDIA Clara
NVIDIA NeMo Megatron
Python

Integrations Supported

Biohub
Evo 2
NVIDIA AI Foundations
NVIDIA Clara
NVIDIA NeMo Megatron
Python

API Availability

Has API

API Availability

Has API

Pricing Information

Free
Free Trial Offered?
Free Version

Pricing Information

Pricing not provided.
Free Trial Offered?
Free Version

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Company Facts

Organization Name

Biohub

Date Founded

2016

Company Location

United States

Company Website

biohub.ai/models/esmc

Company Facts

Organization Name

NVIDIA

Date Founded

1993

Company Location

United States

Company Website

www.nvidia.com/en-us/gpu-cloud/bionemo/

Categories and Features

Categories and Features

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