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What is Gritstone?

At the core of our immunotherapy strategy is our deep understanding of antigens and neoantigens, especially when it comes to pinpointing which variations will be transcribed, translated, processed, and ultimately presented on cell surfaces through Human leukocyte antigen (HLA) molecules, making them identifiable to T cells. We utilize Gritstone EDGETM, an innovative platform that leverages machine learning to facilitate this process. The development of cancer immunotherapies that target tumor-specific neoantigens is particularly challenging due to the multitude of mutations present in tumors, where only a select few translate into true tumor-specific neoantigens. To address this intricate issue, we have engineered EDGE's advanced integrated neural network model, which has been trained on millions of data points sourced from a wide array of tumor and normal tissue samples derived from various patient backgrounds. This comprehensive training significantly boosts our ability to accurately identify neoantigens and enhances the overall effectiveness of our immunotherapy approaches, ultimately aiming to provide more targeted and effective treatments for patients. By continually refining our methods and expanding our databases, we strive to stay at the forefront of cancer immunotherapy advancements.

What is 3decision?

3decision® is a cutting-edge cloud-hosted platform designed to serve as a centralized hub for protein structures, emphasizing effective management of structural data and advanced analytics to accelerate the identification of small molecules and biologics through structure-guided drug design. This platform integrates and standardizes both experimental and computational protein structures from well-known public repositories like RCSB PDB and AlphaFoldDB, as well as proprietary data, while accommodating various file formats including PDBx/mmCIF and ModelCIF. Such a comprehensive strategy ensures easy accessibility to a diverse array of structural data, encompassing X-Ray, NMR, cryo-EM, and modeled structures, thereby fostering collaboration and boosting scientific research efforts. Beyond basic storage capabilities, 3decision® enhances its entries with important metadata and sequence information, detailing aspects such as protein-ligand interactions, antibody information, and binding site features. Its sophisticated analytical tools empower researchers to pinpoint potential druggable sites, assess off-target activities, and compare binding sites, thus transforming vast structural datasets into actionable insights. The platform's cloud-based functionality not only promotes effortless collaboration among research teams but also positions itself as an indispensable asset for driving forward drug discovery projects, ultimately contributing to the advancement of therapeutic solutions. Additionally, its user-friendly interface and robust support for data integration make it a favorite among scientists aiming for innovative breakthroughs in the field.

Media

Media

No images available

Integrations Supported

Additional information not provided

Integrations Supported

Additional information not provided

API Availability

Has API

API Availability

Has API

Pricing Information

Pricing not provided.
Free Trial Offered?
Free Version

Pricing Information

Pricing not provided.
Free Trial Offered?
Free Version

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Company Facts

Organization Name

Gritstone bio

Date Founded

2015

Company Location

United States

Company Website

gritstonebio.com/scientific-platform/

Company Facts

Organization Name

Discngine

Date Founded

2004

Company Location

France

Company Website

www.discngine.com

Categories and Features

Categories and Features

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