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What is Gritstone?

At the core of our immunotherapy strategy is our deep understanding of antigens and neoantigens, especially when it comes to pinpointing which variations will be transcribed, translated, processed, and ultimately presented on cell surfaces through Human leukocyte antigen (HLA) molecules, making them identifiable to T cells. We utilize Gritstone EDGETM, an innovative platform that leverages machine learning to facilitate this process. The development of cancer immunotherapies that target tumor-specific neoantigens is particularly challenging due to the multitude of mutations present in tumors, where only a select few translate into true tumor-specific neoantigens. To address this intricate issue, we have engineered EDGE's advanced integrated neural network model, which has been trained on millions of data points sourced from a wide array of tumor and normal tissue samples derived from various patient backgrounds. This comprehensive training significantly boosts our ability to accurately identify neoantigens and enhances the overall effectiveness of our immunotherapy approaches, ultimately aiming to provide more targeted and effective treatments for patients. By continually refining our methods and expanding our databases, we strive to stay at the forefront of cancer immunotherapy advancements.

What is CZ CELLxGENE Discover?

Select two customized cell groups by leveraging metadata to identify their most distinctly expressed genes. Use the vast repository of millions of cells from the integrated CZ CELLxGENE database for comprehensive analysis. Engage in dynamic examinations of datasets to explore how gene expression patterns are shaped by spatial, environmental, and genetic factors through an intuitive no-code interface. This approach allows researchers to gain insights into existing datasets or utilize them as a springboard to uncover novel cell subtypes and states. Census enables access to any tailored segment of standardized cell data within the CZ CELLxGENE, with options for exploration in both R and Python environments. Immerse yourself in an interactive encyclopedia that features over 700 cell types, complete with detailed definitions, marker genes, lineage details, and related datasets all accessible in a single platform. In addition, researchers can browse and acquire an extensive array of standardized data collections, alongside more than 1,000 datasets that illuminate the functions of both healthy mouse and human tissues, significantly enhancing the study of cellular biology. This resource serves as an invaluable tool for scientists striving to deepen their understanding of cellular dynamics and gene expression, ultimately driving innovation in the field. Furthermore, the user-friendly interface promotes collaborative efforts among researchers, fostering a community of shared knowledge and discoveries.

Media

Media

Integrations Supported

Integrations Supported

Python
R

API Availability

API Availability

Has API

Pricing Information

Pricing not provided

Pricing Information

Pricing not provided

Supported Platforms

SaaS

Supported Platforms

SaaS
Windows
Mac
Linux

Customer Service / Support

Web-Based Support

Customer Service / Support

Web-Based Support

Training Options

Not specified

Training Options

Documentation Hub

Company Facts

Organization Name

Gritstone bio

Date Founded

2015

Company Location

United States

Company Website

gritstonebio.com/scientific-platform/

Company Facts

Organization Name

CZ CELLxGENE

Company Location

United States

Company Website

cellxgene.cziscience.com

Categories and Features

Drug Discovery

Not specified

Categories and Features

Bioinformatics

Not specified

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