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What is Gritstone?

At the core of our immunotherapy strategy is our deep understanding of antigens and neoantigens, especially when it comes to pinpointing which variations will be transcribed, translated, processed, and ultimately presented on cell surfaces through Human leukocyte antigen (HLA) molecules, making them identifiable to T cells. We utilize Gritstone EDGETM, an innovative platform that leverages machine learning to facilitate this process. The development of cancer immunotherapies that target tumor-specific neoantigens is particularly challenging due to the multitude of mutations present in tumors, where only a select few translate into true tumor-specific neoantigens. To address this intricate issue, we have engineered EDGE's advanced integrated neural network model, which has been trained on millions of data points sourced from a wide array of tumor and normal tissue samples derived from various patient backgrounds. This comprehensive training significantly boosts our ability to accurately identify neoantigens and enhances the overall effectiveness of our immunotherapy approaches, ultimately aiming to provide more targeted and effective treatments for patients. By continually refining our methods and expanding our databases, we strive to stay at the forefront of cancer immunotherapy advancements.

What is Echidna?

Echidna is a tool developed using Haskell that focuses on fuzzing and property-based testing for Ethereum smart contracts. It implements sophisticated grammar-driven fuzzing techniques that take advantage of a contract's ABI to test user-defined predicates or Solidity assertions. With its emphasis on modularity, Echidna is designed to be easily expandable, allowing developers to add new mutations or tailor the testing to specific contracts under various scenarios. The tool creates inputs that are finely tuned to your codebase, offering optional functionalities for corpus collection, mutation strategies, and coverage guidance to help identify subtle bugs. By utilizing Slither for the extraction of essential information before the fuzzing process begins, Echidna enhances the effectiveness of its testing. Its integration with source code allows for precise identification of which lines are executed during tests, accompanied by an interactive terminal UI and options for text-only or JSON output formats. Moreover, it features automatic minimization of test cases for more efficient bug triage and fits seamlessly into the overall development workflow. Echidna also tracks maximum gas consumption during fuzzing and accommodates complex contract initialization through Etheno and Truffle, thereby improving its practicality for developers. In conclusion, Echidna is a powerful tool that plays a vital role in ensuring the robustness and security of Ethereum smart contracts, making it an essential asset for developers in the blockchain space.

Media

Media

Integrations Supported

Docker
Etheno
Ethereum
GitHub
Haskell
Homebrew
JSON
Nix
Solidity

Integrations Supported

Docker
Etheno
Ethereum
GitHub
Haskell
Homebrew
JSON
Nix
Solidity

API Availability

Has API

API Availability

Has API

Pricing Information

Pricing not provided
Free Version
Free Trial Offered?

Pricing Information

Free
Free Version
Free Trial Offered?

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Company Facts

Organization Name

Gritstone bio

Date Founded

2015

Company Location

United States

Company Website

gritstonebio.com/scientific-platform/

Company Facts

Organization Name

Crytic

Company Website

github.com/crytic/echidna

Categories and Features

Categories and Features

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