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What is Gritstone?

At the core of our immunotherapy strategy is our deep understanding of antigens and neoantigens, especially when it comes to pinpointing which variations will be transcribed, translated, processed, and ultimately presented on cell surfaces through Human leukocyte antigen (HLA) molecules, making them identifiable to T cells. We utilize Gritstone EDGETM, an innovative platform that leverages machine learning to facilitate this process. The development of cancer immunotherapies that target tumor-specific neoantigens is particularly challenging due to the multitude of mutations present in tumors, where only a select few translate into true tumor-specific neoantigens. To address this intricate issue, we have engineered EDGE's advanced integrated neural network model, which has been trained on millions of data points sourced from a wide array of tumor and normal tissue samples derived from various patient backgrounds. This comprehensive training significantly boosts our ability to accurately identify neoantigens and enhances the overall effectiveness of our immunotherapy approaches, ultimately aiming to provide more targeted and effective treatments for patients. By continually refining our methods and expanding our databases, we strive to stay at the forefront of cancer immunotherapy advancements.

What is Elements Contrast Clearance Analysis?

Brainlab's Elements Contrast Clearance Analysis utilizes MRI technology to effectively differentiate between areas of contrast clearance and accumulation in brain tumor imaging datasets. This sophisticated high-resolution technique significantly improves the insight required for ongoing assessments and decision-making in various medical specialties, such as radiosurgery, radiation oncology, neurosurgery, neuro-oncology, and neuroradiology. The process involves obtaining two standard 3D T1-weighted MRIs; the first is captured approximately five minutes after the injection of a standard contrast agent, followed by a second scan taken between 60 to 105 minutes later. By performing a subtraction of the first series from the latter, volumetric maps are generated that distinctly highlight regions of contrast clearance (depicted in blue) and those of contrast accumulation (marked in red). This information empowers healthcare professionals to more accurately gauge the impacts of radiation therapy against the possibility of tumor regrowth, thus facilitating more informed decisions regarding both initial and ongoing treatment strategies. Consequently, this analytical approach not only supports clinical evaluations but also plays a crucial role in enhancing the overall management of patient care in challenging medical scenarios, ultimately leading to improved patient outcomes.

Media

Media

Integrations Supported

Additional information not provided

Integrations Supported

Additional information not provided

API Availability

Has API

API Availability

Has API

Pricing Information

Pricing not provided.
Free Trial Offered?
Free Version

Pricing Information

Pricing not provided.
Free Trial Offered?
Free Version

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Company Facts

Organization Name

Gritstone bio

Date Founded

2015

Company Location

United States

Company Website

gritstonebio.com/scientific-platform/

Company Facts

Organization Name

Brainlab

Date Founded

1989

Company Location

Germany

Company Website

www.brainlab.com/radiosurgery-products/elements/contrast-clearance-analysis/

Categories and Features

Categories and Features

Medical Imaging

Automated Routing
Comparison View
Compliance Management
Data Import / Export
Diagnostic Reporting
Image Analytics
Treatment Planning
Workflow Management

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