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What is SILCS?

Site-Identification by Ligand Competitive Saturation (SILCS) generates three-dimensional representations called FragMaps, which depict the interactions of various chemical functional groups with a designated target molecule. By uncovering the intricacies of molecular dynamics, SILCS provides essential tools that facilitate the refinement of ligand scaffolds, offering both qualitative and quantitative perspectives on binding sites, which ultimately aids in optimizing the drug design workflow. This methodology utilizes a selection of small molecule probes, each possessing a variety of functional groups, along with explicit solvent modeling and the flexibility of the target molecule to effectively map protein targets. Moreover, the technique empowers researchers to visualize beneficial interactions with the target macromolecule, allowing for a more informed design process. Armed with these insights, scientists can strategically engineer enhanced ligands with functional groups positioned for maximum efficacy. The pioneering approach of SILCS marks a noteworthy leap forward in the realm of medicinal chemistry, opening new avenues for drug discovery and development. Through its advanced analytical capabilities, SILCS not only enhances understanding but also drives innovation in therapeutic design.

What is Nanome?

Nanome is an innovative platform that facilitates collaborative molecular visualization and enhances drug discovery efforts. Users can conveniently upload protein and small-molecule structures to analyze together in a three-dimensional view, which can be accessed via web browsers or various XR headsets, including the Meta Quest 3 and 3S, Apple Vision Pro, and Samsung Galaxy XR. In a collaborative session, participants, such as a chemist using a headset alongside a colleague on a laptop, can collectively focus on the same molecular aspects regardless of their physical locations. The platform is equipped with MARA, an AI copilot that adeptly handles tasks such as docking, co-folding, electrostatics calculations, and ADMET predictions by interpreting simple, natural language commands and utilizes more than 300 integrated scientific tools to generate 3D models for deeper analysis. Furthermore, Nanome accommodates a wide range of file formats including PDB, mmCIF, SDF, MOL2, PyMOL, and Maestro, and it connects seamlessly with various platforms like Schrodinger LiveDesign, OpenEye, Cresset Flare, CDD Vault, KNIME, and Jupyter. For enterprises, deployment options are available in single-tenant or on-premises configurations, which bolster security and governance. Users can access a free web seat, and there's a trial period of 14 days that does not require a credit card for initiation. By bridging the gap between technology and molecular science, Nanome is truly transforming the collaborative landscape for research teams.

Media

Media

No images available

Integrations Supported

Additional information not provided

Integrations Supported

Additional information not provided

API Availability

API Availability

Pricing Information

Pricing not provided

Pricing Information

$20.83/month/user (academic)
Free Version
Free Trial Offered?

Supported Platforms

SaaS

Supported Platforms

SaaS
Windows
On-Prem

Customer Service / Support

Standard Support
Web-Based Support

Customer Service / Support

Web-Based Support

Training Options

Documentation Hub

Training Options

Documentation Hub
Webinars
Online Training

Company Facts

Organization Name

SilcsBio

Date Founded

2012

Company Location

United States

Company Website

silcsbio.com/software/

Company Facts

Organization Name

Nanome

Date Founded

2015

Company Location

United States

Company Website

nanome.ai

Categories and Features

Drug Discovery

Not specified

Categories and Features

Drug Discovery

Not specified

Molecular Modeling

Not specified

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