What is BIOVIA COSMOtherm?

BIOVIA COSMOtherm is an advanced software application that employs the COSMO-RS methodology, integrating quantum chemistry with thermodynamic principles to predict the thermodynamic properties of liquid compounds. It analyzes the chemical potential of molecules in both pure and mixed liquid forms across a range of temperatures, which enables the assessment of various characteristics such as solubility, partition coefficients, vapor pressures, and phase diagrams. Unlike alternative methods, COSMOtherm relies on thermodynamically consistent equations to calculate properties based on concentration and temperature, thereby improving its precision. This tool provides predictions for the solubility of liquids, solids, and gases, along with activity coefficients, two-phase partitioning like LogP, phase behavior, vapor pressures, free energy of solvation, pKa values, energy of transfer to liquid-liquid interfaces, micellar and membrane partitioning, and interfacial tension. Furthermore, COSMOtherm features an intuitive graphical interface in addition to a command-line option, enabling seamless incorporation into existing workflows, which enhances its adaptability for researchers. With its extensive functionality, COSMOtherm stands out as an indispensable resource for those aiming to gain deeper insights into the intricate behavior of liquid systems. Researchers can leverage this tool not only for theoretical predictions but also for practical applications in various scientific fields.

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Screenshots and Video

BIOVIA COSMOtherm Screenshot 1
BIOVIA COSMOtherm Screenshot 1 BIOVIA COSMOtherm Screenshot 2

Company Facts

Company Name:
Dassault Systèmes
Date Founded:
1981
Company Location:
France
Company Website:
www.3ds.com/products/biovia/cosmo-rs/cosmotherm

Product Details

Deployment
Windows
Training Options
Documentation Hub
Online Training
Webinars
On-Site Training
Video Library
Support
Standard Support
24 Hour Support
Web-Based Support

Product Details

Target Company Sizes
Individual
1-10
11-50
51-200
201-500
501-1000
1001-5000
5001-10000
10001+
Target Organization Types
Mid Size Business
Small Business
Enterprise
Freelance
Nonprofit
Government
Startup
Supported Languages
English

BIOVIA COSMOtherm Categories and Features

Chemical Software

Certificates of Analysis
Chemical Process Simulation
Computer-Assisted Structure Elucidation (CASE)
ISO Management
Inventory Management
Particle Tracking
Reporting & Statistics
Samples Tracking
Traceability
Uncertainty Analysis

BIOVIA COSMOtherm Customer Reviews

Write a Review
  • Reviewer Name: Ramakrishna K.
    Position: Simulation & modelling specialist
    Has used product for: 2+ Years
    Uses the product: Daily
    Org Size (# of Employees): 20,000 or More
    Feature Set
    Layout
    Ease Of Use
    Cost
    Customer Service
    Would you Recommend to Others?
    1 2 3 4 5 6 7 8 9 10

    Predictive Power Unleashed: A Deep Dive into BIOVIA COSMOtherm

    Date: Oct 28 2025
    Summary

    BIOVIA COSMOtherm delivers a powerful and reliable platform for predicting thermodynamic properties of chemical systems without experimental data. Its COSMO-RS-based modeling is impressively accurate for solubility, partitioning, and mixture behavior, making it a go-to tool for formulation scientists and process engineers. The interface is intuitive, and its integration with other BIOVIA tools enhances workflow efficiency. While it demands a solid understanding of physical chemistry and comes with a premium price tag, the value it offers in accelerating R&D and supporting green chemistry initiatives is undeniable

    Positive

    Accurate Property Prediction
    User-Friendly Interface
    Supports Sustainable Innovation
    Versatile Applications

    Negative

    License Cost
    Steep Learning Curve
    Limited for Highly Complex Systems
    Computational Demands

    Read More...
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