List of Cisco Secure Email Threat Defense Integrations
This is a list of platforms and tools that integrate with Cisco Secure Email Threat Defense. This list is updated as of November 2025.
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    Microsoft 365 for Individuals is a powerful ecosystem that blends AI innovation, productivity, and creativity into one cohesive experience. With familiar tools like Word, Excel, PowerPoint, Outlook, and OneNote enhanced by Copilot AI, users can draft, analyze, and organize tasks with unprecedented ease. Microsoft’s AI integration helps users overcome creative blocks, turn ideas into polished designs, and work more efficiently across every device. Through OneDrive’s 1TB of cloud storage per person, all files, photos, and documents remain secure and accessible from anywhere. Microsoft Designer and Clipchamp enable users to create visually stunning content and edit videos with professional precision, all without needing advanced design skills. The addition of Microsoft Defender ensures that privacy and cybersecurity remain at the forefront, protecting devices and personal data. Each plan—from Basic to Premium—offers flexibility to match different lifestyles and budgets while maintaining access to the full suite of AI-powered tools. With support for multiple devices, family sharing options, and real-time collaboration, Microsoft 365 connects people across home, work, and learning environments. Copilot AI personalizes productivity by offering insights, summaries, and creative suggestions that evolve with user habits. Altogether, Microsoft 365 redefines how individuals create, communicate, and manage their lives in a connected digital world.
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Altair Knowledge Hub
Altair
Empower your team with seamless, collaborative data management solutions.Self-service analytics platforms were created to empower users by improving their flexibility and reliance on data. However, this increased flexibility often led to disjointed workflows and a lack of oversight, creating a somewhat disorderly environment for data management. Knowledge Hub addresses these issues by providing a solution tailored for business users while ensuring streamlined governance for IT teams. With its user-friendly browser interface, it automates the process of data transformation, distinguishing itself as the only collaborative data preparation tool currently available. This platform enables business teams to work effectively alongside data engineers and scientists, allowing them to create, validate, and share reliable datasets and analytical models in a customized manner. Importantly, it eliminates the need for coding skills, empowering a broader range of users to engage in data sharing and make informed decisions. Governance, data lineage, and collaborative tasks are efficiently handled through a cloud-ready infrastructure designed to stimulate innovation. Furthermore, its low- to no-code extensibility empowers various stakeholders across the organization to effortlessly transform data, thereby fostering a culture centered on data-driven decision-making. In this manner, Knowledge Hub not only boosts productivity but also cultivates a cohesive strategy for data use across different departments, ultimately leading to better organizational outcomes. Such a comprehensive approach not only optimizes processes but also enhances collaboration among diverse teams. - 
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Splunk User Behavior Analytics
Cisco
Empowering security with advanced behavior analytics and automation.Safeguarding against hidden threats through user and entity behavior analytics is crucial for modern security practices. This methodology reveals deviations and covert risks that traditional security systems frequently miss. By streamlining the synthesis of various anomalies into a unified threat, security professionals can enhance their operational efficiency. Utilize sophisticated investigative tools and strong behavioral baselines that are relevant to any entity, anomaly, or potential threat. Implement machine learning to automate the identification of threats, which allows for a more concentrated approach to threat hunting with precise, behavior-driven alerts that support swift assessment and action. Anomalous entities can be swiftly identified without requiring human involvement, resulting in a more efficient process. With a comprehensive selection of over 65 types of anomalies and more than 25 classifications of threats encompassing users, accounts, devices, and applications, organizations significantly improve their capacity to detect and mitigate risks. This synergy of human expertise and machine-driven insights enables companies to substantially bolster their security frameworks. Ultimately, the adoption of these sophisticated capabilities fosters a more robust and anticipatory defense strategy against constantly evolving threats, ensuring a safer operational environment. - 
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Trellix Detection as a Service
Trellix
Proactively safeguard your workflows with advanced threat detection.Recognize possible threats during every phase of your operational workflows. Scrutinize your cloud framework and the business logic relating to the data stored in your cloud applications. Maintain the integrity of your documents and content by leveraging the latest threat intelligence, complemented by advanced machine learning, artificial intelligence, and correlation engines. Effortlessly connect with your trusted cloud services, online applications, and collaboration tools. Perform scans on files, hashes, and URLs for potential malware in a live virtual setting while ensuring the protection of your internal resources. Integrate Detection as a Service into your Security Operations Center routines, Security Information and Event Management analytics, data storage systems, and applications, among other areas. Evaluate the potential for secondary or cumulative impacts during various stages of the cyber-attack lifecycle to reveal hidden exploits and malware threats. Take advantage of our intuitive Chrome extension to submit MD5 hashes or local files, which can be seamlessly integrated into your current toolsets or workflows to further bolster your security measures. This integration not only optimizes your threat detection capabilities but also significantly enhances your team's ability to tackle new security challenges as they arise, fostering a proactive approach to cybersecurity. - 
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Swimlane
Swimlane
Agentic AI automation for every security functionAt Swimlane, we believe the convergence of agentic AI and automation can solve the most challenging security, compliance, and IT/OT operations problems. Only Swimlane, the first and only AI hyperautomation platform for every security function, gives enterprises and MSSPs the scale and flexibility needed to integrate and automate across their entire security ecosystem. Swimlane’s roots in integrations and automation give us an edge when it comes to building an Agentic AI architecture for the future. - 
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Clearswift ARgon for Email
Fortra
Transform email security with seamless, intelligent data protection.Clearswift's ARgon for Email seamlessly integrates advanced data loss prevention (DLP) features into your existing security infrastructure, enabling swift and effective deployment. Essentially, ARgon provides strong protection against various information threats that may emerge from both inbound and outbound email communications. Its automatic sanitization and redaction capabilities smartly remove only those elements that could lead to potential data breaches, ensuring that secure communications remain uninterrupted. This method significantly reduces the likelihood of false positives commonly associated with traditional stop-and-block DLP solutions, which in turn lessens the burden on IT teams. Furthermore, ARgon for Email enhances organizational visibility and confidence, ensuring that sensitive data shared via email is protected and compliant with industry regulations. As a result, companies can dedicate their efforts to core business activities without the persistent anxiety regarding data security risks. This innovative solution ultimately fosters a more secure and efficient communication environment within organizations. 
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