List of the Top 25 Endpoint Protection Software for Mid Size Business in 2026

ManageEngine's Endpoint Central, which was previously known as Desktop Central, serves as a comprehensive Unified Endpoint Management Solution that oversees enterprise mobility management. This solution encompasses all aspects of mobile app and device management, in addition to client management for various endpoints, including mobile devices, laptops, tablets, servers, and other computing machines. With ManageEngine Endpoint Central, users can streamline and automate numerous desktop management activities, such as software installation, patching, IT asset management, imaging, and operating system deployment, thereby enhancing operational efficiency across the organization. This tool is particularly beneficial for IT departments looking to maintain control over their diverse technology environments.

1Password stands out as a reliable password manager that emphasizes security, scalability, and user-friendliness, earning the trust of numerous prestigious organizations worldwide. With its intuitive interface, 1Password facilitates the protection of employees online, helping cultivate strong security practices that become instinctive as they integrate the tool into their daily routines. Now featuring Advanced Protection options within 1Password Business, users can implement Master Password policies, enforce two-factor authentication for the entire team, impose firewall access restrictions, review login attempts, and ensure everyone is using the latest version of 1Password. Our award-winning applications are available for a variety of platforms including Mac, iOS, Linux, Windows, and Android, ensuring comprehensive accessibility. The seamless synchronization across devices guarantees that employees can retrieve their passwords whenever needed, enhancing both security and productivity. By adopting 1Password, organizations can significantly lower their risk while fostering a more efficient work environment.

Guardz is the unified cybersecurity platform built for MSPs. We consolidate the essential security controls, including identities, endpoints, email, awareness, and more, into one AI-native framework designed for operational efficiency. With an identity-centric approach, an elite threat hunting team, and 24/7 AI + human-led MDR, Guardz transforms cybersecurity from reactive defense into proactive protection.

DriveStrike offers an intuitive solution that is easy to use, implement, and manage. With DriveStrike, users can execute commands for remote wipe, remote lock, or remote location across various platforms. It serves as a mobile device management (MDM) tool tailored for mobile ecosystems while also supporting integrated drive encryption. Our dedicated support team is ready to assist with any inquiries, guide you through the installation process, or help manage your account effectively. Protecting your data and devices has never been simpler than with our services. We are eager to clarify any doubts you may have and provide insights on the best ways to safeguard your information. Secure your business with a comprehensive platform designed to protect devices and data with one unified solution. All of your devices—including workstations, iPads, smartphones, tablets, and laptops—will be organized, secure, and well-protected under our management. This holistic approach ensures that your entire digital environment remains safe from potential threats.

ThreatLocker is a Zero Trust platform designed to prevent cyber threats by ensuring only trusted applications and processes are allowed to operate. It eliminates persistent admin privileges, applies least privilege controls, and gives organizations granular control over how software runs. Through application allowlisting, ringfencing, and storage controls, it blocks ransomware, zero day attacks, and unauthorized behavior before anything can execute. Built for today’s IT and security teams, ThreatLocker delivers centralized control and real time visibility across endpoints, users, and applications. It reduces attack surface, limits lateral movement, and supports compliance with detailed logging and audit trails. With rapid deployment, a continuously maintained application library, and efficient approval processes, organizations can enhance security while lowering operational complexity and maintaining uptime.

Quickly enabling Just-In-Time privilege elevation for all employees is essential for modern security. Both workstations and servers can be efficiently managed and onboarded through a user-friendly portal. Utilizing threat and behavior analysis, organizations can detect and thwart malware attacks and data breaches by pinpointing risky users and assets. Instead of elevating user permissions, applications are elevated, which streamlines the process and cuts costs by assigning privileges based on specific users or groups. Whether it's a seasoned developer in IT or a less experienced staff member in HR, there is an appropriate elevation strategy available for every type of user to effectively manage your endpoints. Admin By Request includes a comprehensive set of features that can be tailored to suit the unique requirements of different users or groups, ensuring a customizable approach to security. This flexibility allows organizations to maintain robust security while accommodating diverse workflows.

Iru AI is a next-generation, AI-native security and compliance platform designed to unify and automate enterprise protection in an increasingly complex digital landscape. Built from the ground up for the AI era, Iru integrates identity management, endpoint protection, and compliance automation within a single, context-aware system. Its proprietary Iru Context Model continuously interprets relationships between users, apps, and devices, enabling intelligent actions across authentication, threat detection, and audit workflows. The Identity module eliminates passwords with device-bound authentication, ensuring frictionless yet secure access to every enterprise app. The Endpoint suite consolidates management, detection, and vulnerability response into one lightweight agent, providing real-time visibility and cross-platform consistency. Meanwhile, the Compliance engine automates control mapping and evidence collection, reducing audit preparation time while maintaining continuous readiness. Unlike fragmented legacy tools, Iru’s unified approach minimizes security gaps, streamlines administration, and improves user experience across the organization. The platform’s scalability and AI automation have helped firms cut IT workloads in half while achieving stronger security postures and regulatory compliance. Trusted by global innovators like Airbus, Notion, McLaren, and BetterHelp, Iru is transforming how enterprises secure their digital ecosystems. With over 5,000 customers and top-tier ratings for usability and innovation, Iru empowers teams to focus on strategic growth rather than operational complexity.

ESET Protect Advanced delivers a robust cybersecurity solution tailored for organizations of various sizes. This platform provides cutting-edge endpoint security to combat ransomware and zero-day vulnerabilities effectively. It features full disk encryption to uphold legal standards and safeguard data integrity. The solution employs adaptive scanning, cloud sandboxing, and behavioral analysis to defend against emerging cloud-based threats proactively. Additionally, mobile threat protection encompasses anti-malware and anti-theft measures for both Android and iOS devices. Beyond this, it includes cloud application security, mail server protection, vulnerability assessment, patch management, and comprehensive cloud app safeguards. Enhancements such as multi-factor authentication and extended detection and response (XDR) bolster threat detection and response capabilities. The system offers a unified remote management interface that allows for seamless visibility into threats and user activities. Furthermore, it provides in-depth reporting and tailored notifications to keep users informed of potential risks and system status. This holistic approach ensures that businesses can maintain a strong security posture in an increasingly complex digital landscape.

Airlock Digital provides application control and allowlisting, used by organizations worldwide to protect against ransomware, malware and other cyber threats. Our deny by default solution enables customers to run only the applications and files they trust, with all others blocked from executing. This approach minimizes attack surfaces and helps organizations align their cybersecurity strategies with government frameworks and standards. By securing endpoints running legacy and new versions of Windows, macOS and Linux, we extend protection across IT and operational technology environments. Airlock Digital delivers endpoint protection to financial services, government, healthcare, manufacturing and other industry organizations of all sizes.

DriveLock’s HYPERSECURE Platform aims to strengthen IT infrastructures against cyber threats effectively. Just as one would naturally secure their home, it is equally vital to ensure that business-critical data and endpoints are protected effortlessly. By leveraging cutting-edge technology alongside extensive industry knowledge, DriveLock’s security solutions provide comprehensive data protection throughout its entire lifecycle. In contrast to conventional security approaches that depend on fixing vulnerabilities after the fact, the DriveLock Zero Trust Platform takes a proactive stance by blocking unauthorized access. Through centralized policy enforcement, it guarantees that only verified users and endpoints can access crucial data and applications, consistently following the principle of never trusting and always verifying while ensuring a robust layer of security. This not only enhances the overall security posture but also fosters a culture of vigilance within organizations.

NinjaOne bolsters endpoint security by implementing monitoring, patch management, and software controls. It utilizes automated notifications to detect unusual activities or unapproved applications. Consistent patch updates safeguard devices against potential vulnerabilities. Technicians can employ remote commands for immediate threat remediation. Additionally, backup capabilities offer further protection against ransomware attacks. Comprehensive reporting offers valuable insights into the security status of endpoints. With NinjaOne, endpoints are maintained in a secure and compliant state.

Eliminate the hassle of handling multiple tools for managing identity, access, devices, and inventory. Rippling consolidates everything into a single, cohesive platform—intimately connected and fueled by comprehensive employee information. Streamline tedious manual processes such as device configuration, access granting, endpoint oversight, and offboarding with just a few clicks. Gain thorough insights into users and hardware, proactively address security vulnerabilities before they turn into threats, all without the necessity of expanding your workforce. Experience the quickest route to scalable, secure IT operations—free from tool clutter and excessive costs.

UTunnel Secure Access offers solutions including Cloud VPN, ZTNA, and Mesh Networking to facilitate secure remote connections and reliable network performance. ACCESS GATEWAY: Our Cloud VPN as a Service allows for the rapid deployment of VPN servers on either Cloud or On-Premise setups. By employing OpenVPN and IPSec protocols, it ensures secure remote connections complemented by policy-driven access controls, enabling businesses to establish a robust VPN network effortlessly. ONE-CLICK ACCESS: The Zero Trust Application Access (ZTAA) feature revolutionizes secure interaction with internal business applications such as HTTP, HTTPS, SSH, and RDP. Users can conveniently access these services via their web browsers without the necessity of any client-side applications. MESHCONNECT: This solution, combining Zero Trust Network Access (ZTNA) and mesh networking, offers detailed access controls tailored to specific business network resources and fosters the formation of secure, interconnected business networks for enhanced collaboration. SITE-TO-SITE VPN: Additionally, the Access Gateway allows for the establishment of secure IPSec Site-to-Site tunnels, which facilitate connections between UTunnel's VPN servers and other network infrastructure components like gateways, firewalls, routers, and unified threat management (UTM) systems, thereby enhancing overall network security. By integrating these features, UTunnel Secure Access is committed to providing comprehensive solutions that meet the evolving needs of modern businesses.

Enhance the security of your workforce with robust and user-friendly access solutions from Cisco Duo. Our cutting-edge access security framework is meticulously crafted to safeguard every user, device, and application, allowing you to concentrate on your core activities. Enjoy secure access for all users and devices across various environments and locations, ensuring peace of mind through complete device visibility and trust. This SaaS solution seamlessly protects all applications while being straightforward to deploy, scalable, and responsive to emerging threats. Duo's access security is essential for shielding applications from compromised credentials and devices, offering extensive coverage that aids in fulfilling compliance mandates. By integrating smoothly with applications, Duo delivers flexible, user-centric security that is easy to implement and administer. For administrators, users, and IT teams alike, this is a practical solution that benefits everyone involved. Essential features such as multi-factor authentication, dynamic device trust, adaptive authentication, and secure single sign-on play vital roles in your journey towards a zero-trust framework. Each of these components contributes to a comprehensive security strategy that evolves with your organization's needs.

Action1 transforms patch management by allowing organizations to swiftly identify and address vulnerabilities, achieving an impressive 99% success rate in patch deployment. Enhance your third-party patching processes, including bespoke software, through Action1’s proprietary Software Repository, expertly managed by security professionals, while also overseeing OS updates in a fully integrated system that ensures functional consistency. Real-time vulnerability detection enables immediate remediation by applying patches, eliminating outdated software, or consolidating documentation for vulnerabilities that are unpatchable through compensating controls. Improve network efficiency when deploying substantial software packages, up to 32Gb, simultaneously, and accelerate patch delivery with Action1’s innovative P2P Distribution technology. Recognized as the most user-friendly patch management solution available, Action1 can be set up within five minutes, allowing for immediate automation of patching through its straightforward interface. With its cloud-native architecture, Action1 is designed to scale infinitely and seamlessly supports both on-site and remote employee systems, servers, and cloud applications without the need for a VPN. As a pioneering patch management provider, Action1 has also become the first vendor to achieve SOC 2 and ISO certifications, further solidifying its commitment to security and reliability in patch management.

Splashtop Remote Support is a comprehensive remote support, remote access, and endpoint management platform designed to help IT teams securely troubleshoot, monitor, manage, and support computers and mobile devices across distributed environments. The platform provides both attended and unattended remote access capabilities for Windows, Mac, Linux, iOS, and Android devices, allowing technicians to connect quickly through session codes or managed endpoint access. Splashtop enables IT professionals to remotely control devices, perform troubleshooting, elevate sessions to administrator privileges, reboot and reconnect systems, access background management tools, and collaborate with multiple technicians during support sessions. The platform includes built-in communication tools such as in-session chat and voice calls that improve interaction between technicians and end users during remote support workflows. Splashtop also integrates with major PSA ticketing and IT service management platforms including Zendesk, Freshservice, Freshdesk, Jira, Spiceworks, and Microsoft Teams, helping organizations streamline ticket handling, workflow automation, and support operations. In addition to remote support, the platform offers Autonomous Endpoint Management features that allow businesses to automate patch management, deploy software updates, monitor device health, manage vulnerabilities, track hardware and software inventory, and enforce centralized endpoint policies across distributed systems. Splashtop places strong emphasis on security through end-to-end encryption, two-factor authentication, endpoint MFA, IP whitelisting, session audit logging, cloud recording, secure cloud and on-premises hosting, and compliance with standards such as SOC 2, SOC 3, ISO/IEC 27001, and GDPR.

Hexnode UEM serves as a comprehensive Unified Endpoint Management solution that enables oversight of devices across various platforms through a centralized interface. It adopts a user-focused strategy, ensuring a smooth management experience throughout the entire lifecycle of devices, from initial enrollment to eventual retirement. This platform is relied upon by businesses of all sizes, from small to medium enterprises to Fortune 500 companies globally, as it provides an extensive array of tools tailored for the demands of today's mobile and modern workforce. Among its offerings are management capabilities for a diverse range of devices, including iOS, iPadOS, Android, Windows, macOS, tvOS, Apple TV, Android TV, and fireOS, accompanied by a user-friendly dashboard that enhances visibility and control over mobile assets within the organization, as well as web filtering for enhanced security measures, location tracking, and an array of other valuable features designed to optimize device management. With the increasing reliance on mobile technology, Hexnode UEM continues to evolve, meeting the needs of dynamic teams and enhancing productivity across various sectors.

AccessPatrol serves as a robust software solution for data loss prevention and managing USB device control, aimed at curbing data leaks to removable media, cloud platforms, and various other exit points for information. This software enables the restriction of numerous peripherals, which include USB storage devices, optical drives, Bluetooth connections, WiFi, FireWire, and mobile phones. Users can configure USB device access permissions to be either Allowed, Read Only, or Blocked, while peripheral identification can be made using criteria such as Vendor ID, Serial Number, and PNP Device ID. Moreover, specific USB drives, external hard drives, imaging devices, and portable technologies can be included in an Allowed List to promote the use of only those devices that have been pre-approved by the company, ensuring tighter control over data management. This level of control not only enhances the security of sensitive data but also promotes compliance with organizational policies regarding data handling.

BrowseControl is a web filtering tool that prevents access to websites by analyzing URLs and categorizing them. It allows for detailed internet restriction policies that can be tailored to individual users, departments, or entire organizational units. In addition to its web filtering capabilities, it also offers features for device management, such as blocking specific applications, filtering port access, and scheduling internet restrictions. The security measures implemented by BrowseControl are maintained through a software agent installed on users' devices, ensuring that the solution remains effective in blocking unauthorized websites and applications even when the devices are used outside the company's network. This level of control helps organizations maintain a secure and compliant digital environment for their employees.

TuxCare aims to combat cyber exploitation on a global scale. With its automated live security patching solutions and long-term support services for Linux and open source software, TuxCare enables numerous organizations to swiftly address vulnerabilities, thereby enhancing their security measures. This innovative approach has made TuxCare a trusted partner for over one million significant entities, including enterprises, government bodies, service providers, educational institutions, and research organizations around the world. By providing these essential services, TuxCare plays a critical role in securing the digital landscape for diverse sectors.

GoodAccess is a cybersecurity solution focused on SASE/SSE, aimed at assisting mid-sized companies in effortlessly adopting Zero Trust Architecture (ZTA), no matter the intricacy or scale of their IT systems. Utilizing a Low-Code/No-Code methodology, GoodAccess allows for rapid, hardware-free implementations that can be completed within hours or days, thereby removing the necessity for extensive internal IT skills. The platform provides smooth integration with both contemporary cloud applications and older systems, ensuring the protection of vital resources for teams working remotely or in hybrid settings. Targeting organizations with employee counts ranging from 50 to 5000 across diverse sectors, GoodAccess is particularly ideal for those leveraging multi-cloud and SaaS frameworks, enhancing their overall security posture significantly. Additionally, this solution empowers companies to stay agile and secure in an increasingly digital landscape, fostering a robust defense against emerging cyber threats.

Syncro serves as a comprehensive business platform designed specifically for managing a successful managed service provider (MSP). Experience the convenience of PSA, RMM, and remote access all bundled into one cost-effective solution. Additionally, you can enhance your productivity even further with seamless integrations to over 50 MSP and business applications that you already utilize. The pricing structure of Syncro is straightforward, offering a single flat fee that covers all PSA, RMM, and remote access functionalities, allowing for unlimited endpoints with no binding contracts or minimum requirements. This simplicity makes it easier for MSPs to budget and plan their services effectively.

Complete cybersecurity solutions and automated patch management for expanding enterprises Avast Ultimate Business Security offers a top-tier next-gen antivirus combined with online privacy features and software for automating patch management, ensuring that your devices, data, and applications remain updated and protected. Key Advantages: * Management from a distance via an online administration console * Advanced device safeguarding through next-gen antivirus * Data security enhanced by Firewall, Ransomware Shield, USB Protection, and Password Protection * Online privacy and security features such as VPN, Web Shield, and Web Control * Efficient patch management system to streamline updates

Files that are not recognized may be downloaded onto your computer, and a duplicate will be forwarded to Threat Labs specialists to assess their safety. It conducts checks on web pages prior to them launching in your browser, enhancing your online browsing experience by providing a safety rating within search engine results. With the implementation of cloud-based proactive AI Detection and Real-Time Outbreak Detection, you receive improved safeguards against emerging malware threats. This system defends against various online security risks, including spam, viruses, hackers, and malware, while Anti-Spyware features shield you from spyware and adware that may compromise your personal information. Our security measures for Windows file servers ensure that your data remains confidential, secure, and inaccessible to cybercriminals. Furthermore, the Advanced File Shredder permanently removes files to avert any chances of unintended recovery. It conducts scans on your computer during idle periods, ensuring that your work is uninterrupted. Thus, this comprehensive solution takes care of your cybersecurity needs, allowing you and your team to focus on business operations without facing costly interruptions or distractions. Ultimately, this protection empowers your organization to operate more efficiently in an increasingly digital landscape.

Heimdal® Endpoint Detection and Response is our exclusive multi-faceted service that offers exceptional capabilities for prevention, threat hunting, and remediation. This service integrates the most cutting-edge threat-hunting technologies available, including Heimdal Next-Gen Antivirus, Heimdal Privileged Access Management, Heimdal Application Control, Heimdal Ransomware Encryption Protection, Heimdal Patch & Asset Management, and Heimdal Threat Prevention. With six modules functioning together harmoniously under a single platform and agent, Heimdal Endpoint Detection and Response provides comprehensive cybersecurity layers necessary for safeguarding your organization against both familiar and unfamiliar online and internal threats. Our advanced product enables rapid and precise responses to complex malware, ensuring that your digital assets are protected while also maintaining your organization's reputation. By consolidating these capabilities, we deliver an efficient solution that addresses the evolving challenges of cybersecurity effectively.