List of the Top 25 Endpoint Protection Software for Nonprofit in 2025

NinjaOne streamlines the most challenging aspects of IT management, serving over 20,000 IT teams with enhanced capabilities. By delivering in-depth insights into endpoints, strong security protocols, and a unified control system, NinjaOne increases operational efficiency, protects sensitive information, and reduces IT costs. This all-encompassing platform provides a diverse set of tools for managing and securing endpoints, such as patch management, mobile device supervision, software deployment, remote assistance, backup solutions, and additional features, all made possible through its wide-ranging IT and security integrations. With its ability to adapt to various IT environments and needs, NinjaOne stands out as a vital resource for modern IT teams.

1Password stands out as a reliable password manager that emphasizes security, scalability, and user-friendliness, earning the trust of numerous prestigious organizations worldwide. With its intuitive interface, 1Password facilitates the protection of employees online, helping cultivate strong security practices that become instinctive as they integrate the tool into their daily routines. Now featuring Advanced Protection options within 1Password Business, users can implement Master Password policies, enforce two-factor authentication for the entire team, impose firewall access restrictions, review login attempts, and ensure everyone is using the latest version of 1Password. Our award-winning applications are available for a variety of platforms including Mac, iOS, Linux, Windows, and Android, ensuring comprehensive accessibility. The seamless synchronization across devices guarantees that employees can retrieve their passwords whenever needed, enhancing both security and productivity. By adopting 1Password, organizations can significantly lower their risk while fostering a more efficient work environment.

ManageEngine's Endpoint Central, which was previously known as Desktop Central, serves as a comprehensive Unified Endpoint Management Solution that oversees enterprise mobility management. This solution encompasses all aspects of mobile app and device management, in addition to client management for various endpoints, including mobile devices, laptops, tablets, servers, and other computing machines. With ManageEngine Endpoint Central, users can streamline and automate numerous desktop management activities, such as software installation, patching, IT asset management, imaging, and operating system deployment, thereby enhancing operational efficiency across the organization. This tool is particularly beneficial for IT departments looking to maintain control over their diverse technology environments.

Heimdal Endpoint Detection and Response is a sophisticated security solution designed to continuously observe, evaluate, and react to threats as they occur. Featuring cutting-edge detection methodologies and a proactive approach to incident management, it delivers strong safeguards for your organization's endpoints, facilitating prompt threat neutralization and reducing the risk of significant harm.

DriveStrike offers an intuitive solution that is easy to use, implement, and manage. With DriveStrike, users can execute commands for remote wipe, remote lock, or remote location across various platforms. It serves as a mobile device management (MDM) tool tailored for mobile ecosystems while also supporting integrated drive encryption. Our dedicated support team is ready to assist with any inquiries, guide you through the installation process, or help manage your account effectively. Protecting your data and devices has never been simpler than with our services. We are eager to clarify any doubts you may have and provide insights on the best ways to safeguard your information. Secure your business with a comprehensive platform designed to protect devices and data with one unified solution. All of your devices—including workstations, iPads, smartphones, tablets, and laptops—will be organized, secure, and well-protected under our management. This holistic approach ensures that your entire digital environment remains safe from potential threats.

To effectively combat ransomware, IT professionals must implement strategies that go beyond merely monitoring for threats. ThreatLocker offers a solution by minimizing attack surfaces through policy-driven endpoint security, shifting the focus from just blocking recognized threats to preventing anything that isn’t expressly permitted. By incorporating features like Ringfencing and other robust controls, organizations can bolster their Zero Trust framework and effectively thwart attacks that exploit existing resources. Explore the comprehensive suite of ThreatLocker’s Zero Trust endpoint security solutions, which includes Allowlisting, Ringfencing, Elevation Control, Storage Control, Network Access Control, Unified Audit, ThreatLocker Ops, Community, Configuration Manager, and Health Center, to enhance your cybersecurity posture today. This proactive approach not only safeguards your network but also empowers your team to maintain greater control over security protocols.

DriveLock’s HYPERSECURE Platform aims to strengthen IT infrastructures against cyber threats effectively. Just as one would naturally secure their home, it is equally vital to ensure that business-critical data and endpoints are protected effortlessly. By leveraging cutting-edge technology alongside extensive industry knowledge, DriveLock’s security solutions provide comprehensive data protection throughout its entire lifecycle. In contrast to conventional security approaches that depend on fixing vulnerabilities after the fact, the DriveLock Zero Trust Platform takes a proactive stance by blocking unauthorized access. Through centralized policy enforcement, it guarantees that only verified users and endpoints can access crucial data and applications, consistently following the principle of never trusting and always verifying while ensuring a robust layer of security. This not only enhances the overall security posture but also fosters a culture of vigilance within organizations.

Huntress provides a comprehensive suite of tools for endpoint protection, detection, and response, backed by a team of dedicated threat hunters available 24/7 to safeguard your organization against the ongoing challenges posed by modern cybercriminals. By effectively shielding your business from various threats, including ransomware and unauthorized access, Huntress tackles the full spectrum of the attack lifecycle. Our skilled security professionals take on the rigorous responsibilities of threat hunting, offering exceptional support and in-depth guidance to counter sophisticated attacks. We carefully assess all suspicious activities, issuing alerts only when a threat is verified or needs attention, which significantly minimizes the typical noise and false alarms seen with other security solutions. Features such as one-click remediation, customized incident reports, and smooth integrations empower even those without extensive security knowledge to adeptly manage cyber incidents through Huntress. This approach not only streamlines incident management but also fortifies your organization’s resilience against the ever-evolving landscape of cyber threats. Ultimately, our commitment to proactive security ensures that your business can focus on growth while we handle the complexities of cyber defense.

With co-managed threat detection and response, deployment can occur in any location. ConnectWise SIEM, which was previously known as Perch, is a co-managed platform for threat detection and response, backed by a dedicated Security Operations Center. This solution is crafted to be both flexible and scalable, catering to businesses of all sizes while allowing customization to meet individual requirements. By utilizing cloud-based SIEM solutions, the time needed for deployment is significantly shortened from several months to just minutes. Our Security Operations Center actively monitors ConnectWise SIEM, providing users with access to essential logs. Additionally, threat analysts are available to assist you immediately upon the installation of your sensor, ensuring prompt support and response. This level of accessibility and expert guidance enhances your security posture right from the start.

Enhance the security of your workforce with robust and user-friendly access solutions from Cisco Duo. Our cutting-edge access security framework is meticulously crafted to safeguard every user, device, and application, allowing you to concentrate on your core activities. Enjoy secure access for all users and devices across various environments and locations, ensuring peace of mind through complete device visibility and trust. This SaaS solution seamlessly protects all applications while being straightforward to deploy, scalable, and responsive to emerging threats. Duo's access security is essential for shielding applications from compromised credentials and devices, offering extensive coverage that aids in fulfilling compliance mandates. By integrating smoothly with applications, Duo delivers flexible, user-centric security that is easy to implement and administer. For administrators, users, and IT teams alike, this is a practical solution that benefits everyone involved. Essential features such as multi-factor authentication, dynamic device trust, adaptive authentication, and secure single sign-on play vital roles in your journey towards a zero-trust framework. Each of these components contributes to a comprehensive security strategy that evolves with your organization's needs.

Cynet provides Managed Service Providers (MSPs) and Managed Security Service Providers (MSSPs) with a comprehensive, fully managed cybersecurity platform that integrates vital security features into a single, easily navigable solution. This consolidation not only streamlines the management of cybersecurity but also minimizes complexity and reduces expenses, thereby eliminating the necessity for engaging multiple vendors and managing various integrations. With its multi-layered approach to breach protection, Cynet ensures strong security across endpoints, networks, and SaaS/Cloud environments, effectively safeguarding against the constantly evolving landscape of cyber threats. The platform's sophisticated automation capabilities significantly improve incident response, allowing for rapid detection, prevention, and resolution of potential security issues. Additionally, Cynet’s dedicated CyOps team, backed by a 24/7 Security Operations Center (SOC), continually monitors client environments and provides expert advice to maintain optimal security. Collaborating with Cynet enables you to offer state-of-the-art, proactive cybersecurity services while enhancing your operational efficiency. Discover how Cynet can transform your security services and empower your clients to navigate the complexities of the digital landscape with confidence and resilience. By choosing Cynet, you position your organization at the forefront of cybersecurity innovation, ensuring that you remain competitive in a rapidly evolving market.

UTunnel Secure Access offers solutions including Cloud VPN, ZTNA, and Mesh Networking to facilitate secure remote connections and reliable network performance. ACCESS GATEWAY: Our Cloud VPN as a Service allows for the rapid deployment of VPN servers on either Cloud or On-Premise setups. By employing OpenVPN and IPSec protocols, it ensures secure remote connections complemented by policy-driven access controls, enabling businesses to establish a robust VPN network effortlessly. ONE-CLICK ACCESS: The Zero Trust Application Access (ZTAA) feature revolutionizes secure interaction with internal business applications such as HTTP, HTTPS, SSH, and RDP. Users can conveniently access these services via their web browsers without the necessity of any client-side applications. MESHCONNECT: This solution, combining Zero Trust Network Access (ZTNA) and mesh networking, offers detailed access controls tailored to specific business network resources and fosters the formation of secure, interconnected business networks for enhanced collaboration. SITE-TO-SITE VPN: Additionally, the Access Gateway allows for the establishment of secure IPSec Site-to-Site tunnels, which facilitate connections between UTunnel's VPN servers and other network infrastructure components like gateways, firewalls, routers, and unified threat management (UTM) systems, thereby enhancing overall network security. By integrating these features, UTunnel Secure Access is committed to providing comprehensive solutions that meet the evolving needs of modern businesses.

Rippling simplifies human resources, payroll, IT, and expense management for companies operating on a global scale. With ease, you can oversee the complete employee lifecycle, encompassing everything from recruitment to benefits management and performance evaluations. It offers automation for HR processes, eases the approval workflow, and guarantees adherence to regulations. You can also control devices, manage software access, and monitor compliance, all from a single dashboard. With timely payroll processing, effective expense tracking, and adaptable financial policies, you can save time, lower expenses, and boost overall efficiency in your organization. Discover the advantages of integrated management solutions with Rippling and transform the way your business operates today.

SafeDNS is dedicated to fostering a more secure and protected internet space for small to medium-sized businesses, large corporations, internet service providers, managed service providers, original equipment manufacturers, and educational institutions. Our reach spans across the globe, enhancing online safety for millions of individuals across more than 60 nations. With extensive expertise in cybersecurity and DNS filtering, we provide state-of-the-art solutions that ensure your online safety. Our advanced technologies are designed to shield you from threats such as malware, phishing scams, and unsuitable content, among other risks. Currently, SafeDNS supports over 4,000 organizations and individual users worldwide, demonstrating our commitment to a safer digital landscape for all. As we continue to innovate, our goal is to expand our services and enhance protection for even more users in the future.

SecPod SanerNow stands out as a premier unified platform for endpoint security and management, empowering IT and security teams to streamline and automate essential cyber hygiene processes. Utilizing a sophisticated agent-server framework, it guarantees robust endpoint security alongside efficient management capabilities. The platform excels in vulnerability management by providing comprehensive scanning, detection, assessment, and prioritization features. Available for both on-premise and cloud deployment, SanerNow seamlessly integrates with patch management systems to facilitate automatic updates across major operating systems like Windows, macOS, and Linux, as well as numerous third-party software applications. What truly sets it apart is its expansion into additional critical functionalities, which include security compliance management and IT asset tracking. Moreover, users can leverage capabilities for software deployment, device control, and endpoint threat detection and response. All of these operations can be conducted remotely and automated, reinforcing defenses against the evolving threats posed by modern cyberattacks. This versatile platform not only enhances security but also simplifies the management of IT assets, making it an invaluable tool for organizations of all sizes.

Provide remote assistance to both client and internal systems through unattended access, enabling users to connect to their computers from afar. Whether you're new to remote support solutions or seeking a cost-effective alternative to pricier options, Splashtop Remote Support is an ideal choice. This top-tier remote support solution facilitates seamless access to your managed devices from any platform, ensuring you can connect anytime, backed by our rapid, high-definition connections. With Splashtop, remote management becomes efficient and user-friendly, enhancing productivity for both support teams and users alike.

TuxCare aims to combat cyber exploitation on a global scale. With its automated live security patching solutions and long-term support services for Linux and open source software, TuxCare enables numerous organizations to swiftly address vulnerabilities, thereby enhancing their security measures. This innovative approach has made TuxCare a trusted partner for over one million significant entities, including enterprises, government bodies, service providers, educational institutions, and research organizations around the world. By providing these essential services, TuxCare plays a critical role in securing the digital landscape for diverse sectors.

GoodAccess is a cybersecurity solution focused on SASE/SSE, aimed at assisting mid-sized companies in effortlessly adopting Zero Trust Architecture (ZTA), no matter the intricacy or scale of their IT systems. Utilizing a Low-Code/No-Code methodology, GoodAccess allows for rapid, hardware-free implementations that can be completed within hours or days, thereby removing the necessity for extensive internal IT skills. The platform provides smooth integration with both contemporary cloud applications and older systems, ensuring the protection of vital resources for teams working remotely or in hybrid settings. Targeting organizations with employee counts ranging from 50 to 5000 across diverse sectors, GoodAccess is particularly ideal for those leveraging multi-cloud and SaaS frameworks, enhancing their overall security posture significantly. Additionally, this solution empowers companies to stay agile and secure in an increasingly digital landscape, fostering a robust defense against emerging cyber threats.

Complete cybersecurity solutions and automated patch management for expanding enterprises Avast Ultimate Business Security offers a top-tier next-gen antivirus combined with online privacy features and software for automating patch management, ensuring that your devices, data, and applications remain updated and protected. Key Advantages: * Management from a distance via an online administration console * Advanced device safeguarding through next-gen antivirus * Data security enhanced by Firewall, Ransomware Shield, USB Protection, and Password Protection * Online privacy and security features such as VPN, Web Shield, and Web Control * Efficient patch management system to streamline updates

Files that are not recognized may be downloaded onto your computer, and a duplicate will be forwarded to Threat Labs specialists to assess their safety. It conducts checks on web pages prior to them launching in your browser, enhancing your online browsing experience by providing a safety rating within search engine results. With the implementation of cloud-based proactive AI Detection and Real-Time Outbreak Detection, you receive improved safeguards against emerging malware threats. This system defends against various online security risks, including spam, viruses, hackers, and malware, while Anti-Spyware features shield you from spyware and adware that may compromise your personal information. Our security measures for Windows file servers ensure that your data remains confidential, secure, and inaccessible to cybercriminals. Furthermore, the Advanced File Shredder permanently removes files to avert any chances of unintended recovery. It conducts scans on your computer during idle periods, ensuring that your work is uninterrupted. Thus, this comprehensive solution takes care of your cybersecurity needs, allowing you and your team to focus on business operations without facing costly interruptions or distractions. Ultimately, this protection empowers your organization to operate more efficiently in an increasingly digital landscape.

Cyberthreats can be effectively eliminated, fostering a sense of security among users. The conventional antivirus solutions are no longer adequate in today's fast-evolving landscape. Malwarebytes proactively detects and neutralizes emerging threats even before traditional antivirus programs are aware of their presence. This advanced software is capable of blocking a wide range of dangers, including viruses, malware, harmful websites, ransomware, hackers, and other risks that standard antivirus programs often fail to address. Organizations of every size are adopting our innovative protection and response methodologies. Unlike traditional antivirus solutions, which tend to lag in addressing new threats, our system employs advanced techniques. Our multi-layered approach incorporates anomaly detection, a form of artificial intelligence, along with behavior matching and application hardening to obliterate previously unseen malware. This proactive strategy sets us apart from conventional antivirus tools and enhances overall cybersecurity. By continuously evolving our defenses, we ensure that users can navigate the digital landscape with greater peace of mind.

Trio transforms conventional management techniques in multiple fields, such as corporate environments and educational facilities, by providing efficient, automated, and secure solutions. This cutting-edge mobile device management system is crafted to exceed your expectations regarding both security and productivity. In addition to device management, Trio also integrates vulnerability management, endpoint detection and response (EDR), compliance tracking, and offers extensive visibility into all endpoints, thereby improving overall oversight. With Trio, organizations can not only enhance their operational efficiency but also ensure robust security measures are in place across all devices.

CrowdStrike Falcon is an advanced cloud-based cybersecurity solution designed to provide strong protection against a wide range of cyber threats, including malware, ransomware, and sophisticated attacks. Leveraging artificial intelligence and machine learning, it allows for immediate detection and reaction to potential security breaches, featuring capabilities such as endpoint protection, threat intelligence, and incident management. The platform uses a lightweight agent that continuously monitors endpoints for signs of malicious activity, ensuring security without significantly impacting system performance. Its cloud infrastructure allows for rapid updates, flexibility, and quick threat mitigation across large and diverse networks. With its comprehensive array of security tools, Falcon equips organizations to proactively thwart, detect, and manage cyber threats, making it a vital asset for modern enterprise cybersecurity. Furthermore, its ability to seamlessly integrate with existing systems not only enhances security measures but also helps to minimize disruptions in operational workflows, reinforcing its value in a rapidly evolving digital landscape. The ongoing commitment to innovation ensures that users remain equipped to face the ever-changing cybersecurity landscape with confidence.

The Business Hub serves as a comprehensive, cloud-based platform designed to provide total security solutions. It integrates all crucial security measures necessary to protect a business from cyber threats, ensuring coverage for users and devices no matter their location or time of access. Previously referred to as CloudCare, the Business Hub features an intuitive interface that enhances user experience while maintaining robust security protocols. This transformation highlights the platform's commitment to adapting to the evolving needs of modern businesses.

An exceptionally groundbreaking platform. Unrivaled speed. Infinite scalability. Singularity™ delivers unmatched visibility, premium detection features, and autonomous response systems. Discover the power of AI-enhanced cybersecurity that encompasses the whole organization. The leading enterprises globally depend on the Singularity platform to detect, prevent, and manage cyber threats with astonishing rapidity, expansive reach, and improved accuracy across endpoints, cloud infrastructures, and identity oversight. SentinelOne provides cutting-edge security through this innovative platform, effectively protecting against malware, exploits, and scripts. Designed to meet industry security standards, the SentinelOne cloud-based solution offers high performance across diverse operating systems such as Windows, Mac, and Linux. With its ongoing updates, proactive threat hunting, and behavioral AI capabilities, the platform is adept at addressing any new threats, guaranteeing thorough protection. Additionally, its flexible design empowers organizations to remain ahead of cybercriminals in a continuously changing threat environment, making it an essential tool for modern cybersecurity strategies.