List of the Top 8 Endpoint Protection Software for Autotask PSA in 2025

NinjaOne streamlines the most challenging aspects of IT management, serving over 20,000 IT teams with enhanced capabilities. By delivering in-depth insights into endpoints, strong security protocols, and a unified control system, NinjaOne increases operational efficiency, protects sensitive information, and reduces IT costs. This all-encompassing platform provides a diverse set of tools for managing and securing endpoints, such as patch management, mobile device supervision, software deployment, remote assistance, backup solutions, and additional features, all made possible through its wide-ranging IT and security integrations. With its ability to adapt to various IT environments and needs, NinjaOne stands out as a vital resource for modern IT teams.

Heimdal Endpoint Detection and Response is a sophisticated security solution designed to continuously observe, evaluate, and react to threats as they occur. Featuring cutting-edge detection methodologies and a proactive approach to incident management, it delivers strong safeguards for your organization's endpoints, facilitating prompt threat neutralization and reducing the risk of significant harm.

Enhance the security of your workforce with robust and user-friendly access solutions from Cisco Duo. Our cutting-edge access security framework is meticulously crafted to safeguard every user, device, and application, allowing you to concentrate on your core activities. Enjoy secure access for all users and devices across various environments and locations, ensuring peace of mind through complete device visibility and trust. This SaaS solution seamlessly protects all applications while being straightforward to deploy, scalable, and responsive to emerging threats. Duo's access security is essential for shielding applications from compromised credentials and devices, offering extensive coverage that aids in fulfilling compliance mandates. By integrating smoothly with applications, Duo delivers flexible, user-centric security that is easy to implement and administer. For administrators, users, and IT teams alike, this is a practical solution that benefits everyone involved. Essential features such as multi-factor authentication, dynamic device trust, adaptive authentication, and secure single sign-on play vital roles in your journey towards a zero-trust framework. Each of these components contributes to a comprehensive security strategy that evolves with your organization's needs.

Guardz is an advanced cybersecurity solution driven by AI, designed to equip Managed Service Providers (MSPs) with the tools necessary to safeguard and insure small to medium-sized enterprises against cyber threats. This platform offers automated detection and response mechanisms that shield users, devices, cloud directories, and sensitive data from potential attacks. By streamlining cybersecurity management, it enables businesses to concentrate on their expansion without the burden of complicated security measures. Additionally, the pricing structure of Guardz is both scalable and economical, providing thorough protection for digital assets while promoting swift implementation and supporting business development. Moreover, its user-friendly interface ensures that even those without extensive technical knowledge can effectively manage their cybersecurity needs.

This EDR solution is designed to reveal the untapped capabilities of your network. Utilizing ESET's comprehensive Endpoint Protection Platform, this tool effectively identifies and manages endpoint security issues. It channels all relevant data to ESET Enterprise Inspector, which processes vast amounts of real-time information from endpoints. With impressive speed, it can pinpoint and resolve any security vulnerabilities within the network. ESET Enterprise Inspector features a distinctive reputation-based detection approach that remains unobtrusive for security personnel. For enhanced customization, users can easily modify all rules through XML. You also have the flexibility to develop new rules tailored to the specific requirements of your organization, including seamless integrations with SIEM systems. ESET's endpoint detection and response tool simplifies the management of false positives, allowing you to fine-tune detection sensitivity across various user groups or computer categories. By combining criteria such as file name, path, hash, command line, and signer, you can precisely adjust the conditions under which alerts are triggered, ensuring a tailored security approach. This level of customization empowers organizations to enhance their overall security posture effectively.

Acronis Cyber Protect offers reassurance by ensuring that your business is shielded against threats such as zero-day malware and ransomware, while also providing backup solutions and forensic analysis. With the rapid evolution of cyber threats, relying on basic data backup and cybersecurity measures is no longer sufficient to keep them at bay. Acronis provides comprehensive cyber protection that integrates cybersecurity, data backup, disaster recovery, and additional features to maintain the security of your essential data and systems. Many businesses find themselves relying on a convoluted mix of tools to protect against data loss and cyber threats, but this fragmented approach can create management challenges and leave vulnerabilities. In contrast, Acronis’ unified cyber protection offerings effectively secure complete workloads with improved efficiency and reduced complexity, allowing your team to prioritize protection and strategic initiatives instead of managing disparate solutions. Easily safeguard entire workloads without complications, as getting started with Acronis' cyber protection solutions is both straightforward and seamless. You can provision numerous systems with just a single click and oversee everything—from backup policies to vulnerability assessments and patch management—through a unified interface, streamlining your cybersecurity efforts.

Provide remote assistance to both client and internal systems through unattended access, enabling users to connect to their computers from afar. Whether you're new to remote support solutions or seeking a cost-effective alternative to pricier options, Splashtop Remote Support is an ideal choice. This top-tier remote support solution facilitates seamless access to your managed devices from any platform, ensuring you can connect anytime, backed by our rapid, high-definition connections. With Splashtop, remote management becomes efficient and user-friendly, enhancing productivity for both support teams and users alike.

ConnectWise Cybersecurity Management, which was previously known as ConnectWise Fortify, provides software and support services that enable Managed Service Providers (MSPs) to safeguard their clients' essential business assets. By offering round-the-clock threat detection, incident response, and tools for security risk assessments, these solutions simplify the process of creating a cybersecurity framework powered by MSPs, while also reducing the expenses related to continuous monitoring and support personnel. Consequently, MSPs can focus more on their core services without the added burden of cybersecurity complexities.