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What is Biohub?

Biohub is a user-friendly platform focused on enhancing the comprehension of protein biology. It provides access to the ESM model family, which features ESMC, ESMFold2, and ESM3, as well as interactive tools and resources specifically designed for developers engaged in protein science research. ESMC is recognized as a state-of-the-art protein language model, carefully trained on extensive evolutionary sequence data, enabling it to generate representations that clarify fundamental mechanisms related to protein structure and function. This model supports a variety of applications, including functional analysis, structural predictions, protein design, and exploring evolutionary relationships among diverse proteins. In addition, ESMFold2 excels in predicting high-resolution, all-atom 3D structures of biomolecular complexes from sequences, and it allows for the incorporation of multiple sequence alignments to enhance accuracy for challenging targets. Furthermore, ESM3 adopts a comprehensive methodology by concurrently modeling sequence, structure, and function, which facilitates the innovative design of new proteins through a synergistic approach. This remarkable combination of tools and models equips researchers with the means to push the boundaries of protein science, fostering groundbreaking discoveries that could transform the field. Overall, Biohub's offerings represent a significant leap forward in our ability to manipulate and understand protein interactions and functionalities.

What is Aurora Drug Discovery?

Aurora applies concepts from quantum mechanics and thermodynamics alongside an advanced continuous water model to evaluate solvation effects when determining the binding affinities of ligands. This approach is notably different from the conventional scoring functions that are commonly used to predict binding affinities. By incorporating both entropy and aqueous electrostatic elements into their calculations, the algorithms developed by Aurora provide notably more accurate and dependable estimates of binding free energies. The binding free energy, a key thermodynamic measure, fundamentally dictates the interaction between a ligand and a protein and is directly associated with the experimentally measurable inhibition constant (IC50). Various elements, such as electrostatic interactions, quantum phenomena, solvation dynamics, and the statistical behavior of molecules, all play a role in influencing this free energy (F). The non-additive characteristics of F arise primarily from two key components: the synergistic effects of electrostatic and solvation energies, as well as the entropy present in the system. Gaining a comprehensive understanding of these factors enhances the insight into the molecular interactions that are crucial for effective drug design and development.

Media

Media

Integrations Supported

ESMC
ESMFold2

Integrations Supported

ESMC
ESMFold2

API Availability

Has API

API Availability

Has API

Pricing Information

Pricing not provided.
Free Trial Offered?
Free Version

Pricing Information

Pricing not provided.
Free Trial Offered?
Free Version

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Company Facts

Organization Name

Biohub

Date Founded

2016

Company Location

United States

Company Website

biohub.ai/

Company Facts

Organization Name

Aurora Fine Chemicals

Date Founded

1990

Company Location

United States

Company Website

aurorafinechemicals.com/drug-discovery-software.html

Categories and Features

Categories and Features

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