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What is ESMFold2?

Building upon its predecessor, ESMFold, ESMFold2 sets a new standard in the realm of single-sequence structure prediction while also enabling the design of novel functional proteins by delving into the latent space of the ESMC model. This sophisticated model can accurately predict high-resolution, all-atom 3D structures of biomolecular complexes directly from amino acid sequences and incorporates multiple sequence alignments to enhance accuracy for challenging targets. Designed to predict structures using both sequence and structural modalities, it utilizes ESM representations that power a sequence of looped folding layers, while a diffusion model converts pairwise representations into atomic-resolution results. ESMFold2 stands out in its ability to forecast protein structures from amino acid sequences, providing comprehensive structural information, including exact all-atom coordinates for backbone and side chains, as well as confidence metrics and optional distogram predictions for thorough structural analysis. In addition, its groundbreaking methodology deepens the understanding of protein folding dynamics and their functional implications, positioning it as an indispensable tool for researchers engaging in this area of study. Ultimately, ESMFold2 not only advances structural biology but also opens new avenues for the development of protein-based applications.

What is BIOVIA Materials Studio?

BIOVIA Materials Studio is a comprehensive platform designed for modeling and simulation, aimed at aiding researchers in materials science and chemistry to predict and understand the relationship between a material's atomic and molecular structures and its properties and functionalities. By implementing an "in silico first" approach, researchers are able to optimize material performance in a cost-effective virtual environment prior to engaging in physical experimentation. This adaptable software supports a wide range of materials, including catalysts, polymers, composites, metals, alloys, pharmaceuticals, and batteries. It offers extensive capabilities covering quantum, atomistic, mesoscale, statistical, analytical, and crystallization simulations, facilitating the creation of innovative materials across various industries. Furthermore, its features encourage swift innovation, significantly reduce research and development costs through virtual screening, and enhance productivity by automating routine tasks within Pipeline Pilot, ultimately making it a vital resource for contemporary material research and development. The broad functionality provided not only improves research efficiency but also ensures that users remain at the cutting edge of advancements in material science, continually pushing the boundaries of what is possible.

Media

Media

Integrations Supported

Biohub
Python

Integrations Supported

Biohub
Python

API Availability

Has API

API Availability

Has API

Pricing Information

Free
Free Trial Offered?
Free Version

Pricing Information

Pricing not provided.
Free Trial Offered?
Free Version

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Company Facts

Organization Name

Biohub

Date Founded

2016

Company Location

United States

Company Website

biohub.ai/models/esmfold2

Company Facts

Organization Name

Dassault Systèmes

Date Founded

1981

Company Location

France

Company Website

www.3ds.com/products/biovia/materials-studio

Categories and Features

Categories and Features

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