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What is Muse?

Microsoft has unveiled Muse, a groundbreaking generative AI model that is set to revolutionize how gameplay ideas are conceived. Collaborating with Ninja Theory, this World and Human Action Model (WHAM) utilizes data from the game Bleeding Edge, enabling it to understand 3D game environments along with the complexities of physics and player dynamics. This proficiency empowers Muse to produce diverse and coherent gameplay sequences, thereby enhancing the creative workflow for developers. Furthermore, the AI possesses the ability to craft game visuals while predicting controller inputs, thus facilitating a more efficient prototyping and artistic exploration phase in game development. By analyzing over 1 billion images and actions, Muse not only demonstrates its promise for game creation but also for the preservation of gaming history, as it has the ability to resurrect classic titles for modern platforms. Even though it is currently in its early stages and produces outputs at a resolution of 300×180 pixels, Muse represents a significant advancement in utilizing AI to aid in game development, aiming to boost human creativity rather than replace it. As Muse continues to develop, it may pave the way for groundbreaking innovations in gaming and the resurgence of cherished classic games, potentially reshaping the entire gaming landscape.

What is ESMFold2?

Building upon its predecessor, ESMFold, ESMFold2 sets a new standard in the realm of single-sequence structure prediction while also enabling the design of novel functional proteins by delving into the latent space of the ESMC model. This sophisticated model can accurately predict high-resolution, all-atom 3D structures of biomolecular complexes directly from amino acid sequences and incorporates multiple sequence alignments to enhance accuracy for challenging targets. Designed to predict structures using both sequence and structural modalities, it utilizes ESM representations that power a sequence of looped folding layers, while a diffusion model converts pairwise representations into atomic-resolution results. ESMFold2 stands out in its ability to forecast protein structures from amino acid sequences, providing comprehensive structural information, including exact all-atom coordinates for backbone and side chains, as well as confidence metrics and optional distogram predictions for thorough structural analysis. In addition, its groundbreaking methodology deepens the understanding of protein folding dynamics and their functional implications, positioning it as an indispensable tool for researchers engaging in this area of study. Ultimately, ESMFold2 not only advances structural biology but also opens new avenues for the development of protein-based applications.

Media

Media

Integrations Supported

Biohub
GPT-5.4 mini
GPT-5.4 nano
GPT-5.6
Hugging Face
Microsoft Foundry
Python

Integrations Supported

Biohub
GPT-5.4 mini
GPT-5.4 nano
GPT-5.6
Hugging Face
Microsoft Foundry
Python

API Availability

Has API

API Availability

Has API

Pricing Information

Pricing not provided.
Free Trial Offered?
Free Version

Pricing Information

Free
Free Trial Offered?
Free Version

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Company Facts

Organization Name

Microsoft

Date Founded

1975

Company Location

United States

Company Website

microsoft.com

Company Facts

Organization Name

Biohub

Date Founded

2016

Company Location

United States

Company Website

biohub.ai/models/esmfold2

Categories and Features

Categories and Features

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