List of the Top 25 Endpoint Protection Software for Microsoft 365 in 2025

Kandji is a specialized solution for managing Apple devices, designed specifically for IT departments within organizations that utilize Apple products. This cloud-based platform enables comprehensive management and security of various devices, including Mac computers, iPhones, iPads, and Apple TVs, thereby significantly reducing the time IT teams spend on repetitive manual tasks. Additionally, it offers over 150 pre-built automations and applications to further streamline operations and enhance productivity. With its user-friendly interface and robust features, Kandji empowers IT professionals to focus on strategic initiatives rather than mundane maintenance.

Syncro serves as a comprehensive business platform designed specifically for managing a successful managed service provider (MSP). Experience the convenience of PSA, RMM, and remote access all bundled into one cost-effective solution. Additionally, you can enhance your productivity even further with seamless integrations to over 50 MSP and business applications that you already utilize. The pricing structure of Syncro is straightforward, offering a single flat fee that covers all PSA, RMM, and remote access functionalities, allowing for unlimited endpoints with no binding contracts or minimum requirements. This simplicity makes it easier for MSPs to budget and plan their services effectively.

Guardz is an advanced cybersecurity solution driven by AI, designed to equip Managed Service Providers (MSPs) with the tools necessary to safeguard and insure small to medium-sized enterprises against cyber threats. This platform offers automated detection and response mechanisms that shield users, devices, cloud directories, and sensitive data from potential attacks. By streamlining cybersecurity management, it enables businesses to concentrate on their expansion without the burden of complicated security measures. Additionally, the pricing structure of Guardz is both scalable and economical, providing thorough protection for digital assets while promoting swift implementation and supporting business development. Moreover, its user-friendly interface ensures that even those without extensive technical knowledge can effectively manage their cybersecurity needs.

Electric is revolutionizing business IT management by offering real-time support to over 30,000 users and centralized IT solutions for more than 600 clients. As a result, companies can achieve up to 50% reduction in IT expenses while ensuring consistent security measures across all devices, applications, and networks. This innovative approach not only enhances operational efficiency but also simplifies the complexities of IT management for businesses of all sizes.

ConnectWise Cybersecurity Management, which was previously known as ConnectWise Fortify, provides software and support services that enable Managed Service Providers (MSPs) to safeguard their clients' essential business assets. By offering round-the-clock threat detection, incident response, and tools for security risk assessments, these solutions simplify the process of creating a cybersecurity framework powered by MSPs, while also reducing the expenses related to continuous monitoring and support personnel. Consequently, MSPs can focus more on their core services without the added burden of cybersecurity complexities.

KACE serves as an all-in-one endpoint management solution that provides centralized control over IT systems throughout the organization. It is designed to streamline the entire process from the initial setup to continuous upkeep, effectively addressing all endpoint security and deployment requirements. By utilizing a unified inventory database, KACE enables businesses to swiftly deploy, oversee, and manage their devices, which significantly enhances device security through immediate hardware and software identification, patch management, compliance tracking, and real-time monitoring of mobile endpoints. Furthermore, KACE simplifies the complexities of maintaining device security and compliance, allowing organizations to focus on their core activities without worrying about endpoint vulnerabilities.

Rippling simplifies human resources, payroll, IT, and expense management for companies operating on a global scale. With ease, you can oversee the complete employee lifecycle, encompassing everything from recruitment to benefits management and performance evaluations. It offers automation for HR processes, eases the approval workflow, and guarantees adherence to regulations. You can also control devices, manage software access, and monitor compliance, all from a single dashboard. With timely payroll processing, effective expense tracking, and adaptable financial policies, you can save time, lower expenses, and boost overall efficiency in your organization. Discover the advantages of integrated management solutions with Rippling and transform the way your business operates today.

Around the globe, small and medium-sized enterprises (SMEs) can achieve unparalleled freedom of choice by collaborating with JumpCloud. By utilizing its cloud-based open directory platform, JumpCloud streamlines the management and security of identities, access, and devices, allowing IT teams and managed service providers (MSPs) to efficiently support a variety of operating systems including Windows, Mac, Linux, and Android. This innovative solution enables users to manage identities either directly or through their chosen HRIS or productivity tools, while also granting access to numerous on-premises and cloud applications with a single, secure set of credentials. To explore the full potential of this comprehensive platform, consider starting a free 30-day trial of JumpCloud today and experience the benefits firsthand. Embrace the future of IT management and watch your business thrive.

Streamline the complete patching process using Patch Manager Plus to ensure that all production environments remain up-to-date. This versatile tool is offered in both cloud-based and on-premise formats. It includes functionalities like automated scheduling for patch deployments, detection of missing patches, testing for approval, tracking patches, ensuring compliance, and generating reports. Additionally, Patch Manager Plus enables users to produce comprehensive audit and compliance reports, enhancing oversight and management capabilities. By utilizing this software, businesses can significantly reduce downtime and improve their overall IT security posture.

Take control of your cyber threats effectively by using Defense.com, which allows you to identify, prioritize, and monitor all your security risks within a single, streamlined platform. Streamline your cyber threat management with integrated features that cover detection, protection, remediation, and compliance, all within one convenient hub. By utilizing automatically prioritized and tracked threats, you can make informed decisions that bolster your overall defense strategy. Enhance your security posture through proven remediation techniques tailored to each identified risk. When faced with challenges, you can count on the expertise of experienced cyber and compliance consultants who are ready to assist you. Leverage user-friendly tools that integrate smoothly with your existing security investments, reinforcing your cyber defenses further. Gain real-time insights from penetration tests, vulnerability assessments, threat intelligence, and additional resources, all showcased on a central dashboard that emphasizes your specific risks and their severity levels. Each identified threat comes with actionable remediation advice, making it easier to implement effective security improvements. Moreover, your unique attack surface is aligned with powerful threat intelligence feeds, ensuring you remain proactive in the constantly changing realm of cybersecurity. This holistic approach not only addresses current threats but also equips you to foresee and tackle future challenges within your security framework, thereby fostering a proactive security culture. With a focus on continuous improvement and adaptation, you can maintain a resilient defense against emerging cyber threats.

ESET PROTECT Elite is an advanced cybersecurity solution tailored for enterprises, effectively merging extensive detection and response features with a solid multilayered defense architecture. By employing innovative methods such as adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis, it proficiently tackles zero-day vulnerabilities and ransomware threats. This platform offers contemporary endpoint protection for both desktop and mobile devices, alongside server security that guarantees real-time safety of data and mobile threat defenses. Furthermore, it includes full disk encryption, assisting organizations in achieving compliance with data protection regulations. ESET PROTECT Elite also features robust email security capabilities, which provide protection against phishing, malware, and spam, while safeguarding cloud applications such as Microsoft 365 and Google Workspace. With its automated vulnerability management and patching abilities, the solution streamlines the detection and rectification of security weaknesses across all endpoints, encouraging a proactive stance towards cybersecurity. In conclusion, ESET PROTECT Elite stands out as a holistic solution that effectively meets the complex and ever-changing demands posed by contemporary cybersecurity threats, ensuring that organizations remain secure in a digital landscape fraught with risks.

The WithSecure Business Suite delivers a robust endpoint security solution that is implemented on-site, featuring a comprehensive security architecture designed for physical, virtual, and cloud environments, all accessible via a centralized management interface that prioritizes performance, clarity, and optimal IT resource utilization. This system enables organizations to exercise total local control, effectively meeting the highest security standards. It protects assets across public clouds, private cloud setups, and on-premises environments, all managed from a single hub that simplifies the coordination of various security applications. By incorporating automation and user-friendly controls, it alleviates the workload on IT teams while being designed for ease of use and scalability. The WithSecure Business Suite adeptly resolves the security obstacles encountered by businesses, providing flexible options for either self-management or full-service outsourcing through accredited providers. This solution not only optimizes both IT resources and time efficiency but also ensures seamless integration across all devices, establishing a formidable defense against cyber threats while improving overall operational productivity. Additionally, its adaptability makes it suitable for organizations of varying sizes, ensuring that security measures can grow alongside evolving business needs.

The landscape of security has shifted from a simple binary of threats to a more intricate environment where pinpointing harmful entities has become increasingly difficult. In the current climate, depending solely on conventional signature-based antivirus programs is insufficient, especially for combating ransomware and new threats that frequently slip through the cracks. Although next-generation technologies are capable of addressing some vulnerabilities, they do not provide a one-size-fits-all solution, and the use of multiple anti-malware applications on a single device can lead to a fragmented system that struggles to operate cohesively. Compounding this issue, employees are accessing corporate information from a variety of devices and locations, including diverse cloud platforms. Consequently, it is crucial to implement endpoint security that is not only intelligent and streamlined but also integrated, sourced from a trusted vendor. Trend Micro™ OfficeScan™ employs advanced machine learning alongside various threat protection techniques to bridge security gaps across all user interactions and endpoints, thereby ensuring a strong defense against today's sophisticated cyber threats. This holistic strategy not only fortifies security measures but also simplifies the management process for IT teams dealing with the complexities of the modern threat landscape, ultimately leading to a more resilient organizational infrastructure.

Enterprise servers function as central nodes for data exchange, which inherently makes them vulnerable to various threats. Even within a supposedly secure network, it is possible for users or applications without adequate safeguards to unintentionally upload infected files to the server, potentially spreading these threats to other connected systems that access such files. Additionally, expansive organizations may manage hundreds or even thousands of servers, all of which require regular monitoring, configuration adjustments, and maintenance to ensure optimal performance. Today's sophisticated cyber threats can exploit numerous entry points within a network, often leaving behind concealed damage that raises the possibility of reinfection. To combat these challenges, Trend Micro™ ServerProtect™ provides comprehensive protection against a range of threats including viruses, spyware, and rootkits, while also improving the effectiveness of server security operations. This software not only offers real-time malware scanning and detection but also features tools for cleaning and repairing any compromised systems. By simplifying these security processes, ServerProtect enables organizations to sustain a higher security standard while reducing the likelihood of operational interruptions. Ultimately, the integration of such protective measures is vital for safeguarding sensitive data and maintaining business continuity in a digital landscape fraught with risks.

To maintain the security of your endpoints, it is essential to adopt a clear strategy for detecting and prioritizing potential vulnerabilities, reducing your attack surface, and proactively averting security breaches. This approach involves the implementation of protective measures that efficiently counter sophisticated, automated, and targeted threats, such as ransomware, exploits, and fileless attacks. WithSecure Elements Endpoint Protection provides a cloud-native, AI-driven solution that can be rapidly deployed via your web browser and effectively managed from a centralized dashboard. It integrates effortlessly across all your endpoints, safeguarding your organization from a variety of cyber threats. As part of the WithSecure Elements suite, this platform offers an extensive range of services, including vulnerability management, collaboration safeguarding, and detection and response capabilities, all managed from a unified security dashboard. You can opt for individual solutions customized to your specific requirements, or achieve comprehensive security by incorporating all available services for maximum protection. This adaptability guarantees that your organization can remain robust in the face of changing threat landscapes, thereby enhancing your overall cybersecurity posture. Additionally, having such a flexible system means you can scale your defenses as needed, ensuring continued resilience against emerging challenges.

Effective data protection that remains uncompromised provides the flexibility needed to cater to your unique needs. Among the various data loss prevention (DLP) solutions, Digital Guardian distinguishes itself with its ability to apply either a use case-based approach—which targets specific data types or user groups—or a data risk discovery technique that uncovers previously unidentified use cases. By leveraging this risk discovery approach, organizations can gain improved insight into where sensitive data resides, how it travels within the company, and what vulnerabilities may exist, all without the requirement of setting up formal policies. Built on AWS, Digital Guardian simplifies the deployment process while keeping overhead low and scalability high, thereby enhancing the value of your security investments. It offers extensive compatibility with Windows, macOS, and Linux operating systems, as well as support for both browser-based and native applications. Additionally, its innovative “unknown risk” strategy sheds light on the location and movement of sensitive data, revealing associated risks without depending on established policies. Digital Guardian is unique in delivering a cohesive methodology for data discovery and classification, factoring in content, user, and context to ensure robust protection throughout your digital environment. This comprehensive strategy not only boosts data security but also aids in streamlining compliance efforts across varied regulatory frameworks, making it an essential tool for organizations aiming to safeguard their critical information assets. Ultimately, the adaptability and depth of Digital Guardian's solutions make it a formidable ally in navigating the complexities of data protection and compliance.

As cyber threats increasingly evolve and proliferate through new security channels, the level of complexity, expertise, and resources necessary to combat these dangers is also rising significantly. This mounting complexity often leads security teams to feel inundated and challenged in their efforts to stay ahead. For more than twenty years, SilverSky has evolved as a managed security service provider, addressing the security and regulatory needs of small and mid-sized enterprises with clear and cost-effective solutions. Our primary focus is to assist industries that face rigorous regulatory scrutiny. Relying exclusively on perimeter firewalls for monitoring is no longer sufficient; organizations must now manage every point of interaction within their networks. This extensive surveillance includes networks, servers, databases, personnel, and endpoints. A professional Security Operations Center, or SOC as a service, is the most reliable approach to achieve this level of oversight. SilverSky Security Monitoring is committed to managing both perimeter and core security devices, ensuring that businesses not only fulfill but surpass regulatory compliance requirements while bolstering their overall security strength. Our dedication to excellence drives us to continually refine our strategies, enabling us to stay one step ahead of emerging threats and challenges in the cybersecurity landscape. By doing so, we empower our clients to focus on their core business functions with peace of mind.

The Symantec Integrated Cyber Defense (ICD) Platform delivers an extensive array of security offerings, encompassing Endpoint Security, Identity Security, Information Security, and Network Security, to effectively protect both on-premises and cloud environments. As a trailblazer in merging and coordinating security capabilities across various systems, Symantec enables organizations to embrace cloud solutions at their own pace while safeguarding previous investments in essential infrastructure. Recognizing that many organizations rely on a variety of vendors, Symantec introduced the Integrated Cyber Defense Exchange (ICDx), which promotes the smooth integration of third-party solutions and fosters intelligence sharing across the platform. Distinctive in the realm of cyber defense, Symantec's solutions are designed to support all infrastructure types, whether they are entirely on-premises, exclusively cloud-based, or a combination of both, ensuring that every enterprise can achieve adaptable protection tailored to its needs. This emphasis on flexibility and integration not only enhances security but also reinforces Symantec’s status as a leading figure in the comprehensive cyber defense arena. By prioritizing a user-centric approach, Symantec continues to innovate and evolve, shaping the future of cybersecurity for organizations around the globe.

Maintaining the security of endpoint devices is essential for any organization. Those operating in high-risk environments can particularly benefit from specialized products and services designed to enhance their security posture. These advanced solutions are specifically developed for various types of devices, including desktops, laptops, and thin clients. Their foundations are backed by extensive research and government support, which ensures their effectiveness. The offerings encompass a wide array of managed services, continuous security monitoring, and dedicated research and development efforts. The adoption of zero trust architectures plays a critical role in bolstering the security of cloud services by integrating assessments of both device health and user identity for access control. Furthermore, permitting access to corporate resources from unmanaged endpoints can seriously threaten the integrity of the supply chain. By prioritizing both device health and identity verification, organizations can significantly reduce the risks associated with third-party IT interactions. In addition, managed services facilitate the establishment of secure cloud and mobile infrastructures, promoting safer collaboration with external partners. It is imperative that organizations implement robust security measures to safeguard sensitive data and ensure the continuity of their operations. This proactive approach not only enhances security but also builds trust among stakeholders.

The threats faced by an organization's infrastructure have become increasingly aggressive, encompassing a wide range of issues from malware and advanced persistent threats (APTs) to extortion attempts and internal security breaches. In today's business environment, it is crucial to consider the rapid growth of smartphones, tablets, and the consumerization of IT, along with the challenges posed by remote workers, contractors, partners, and essential services hosted in the cloud. As a result, the necessity for robust security protocols has intensified, making them more complex than ever before. To effectively protect your data and systems, it is vital to implement a flexible, multi-layered defense strategy that encompasses every facet of your IT landscape, including the network, perimeter, data, applications, and endpoints, while also identifying and managing vulnerabilities that could potentially place your organization at risk. Activereach provides an extensive array of network security solutions aimed at defending your business against emerging threats, optimizing network performance, and boosting operational efficiencies, all of which contribute to a more secure and resilient infrastructure. Moreover, as the digital landscape keeps changing, maintaining a proactive approach to security is essential not only for immediate protection but also for ensuring long-term organizational success and stability.

MagicEndpoint delivers unparalleled user authentication security while ensuring an exceptional user experience. After the initial unlocking of the endpoint, users gain seamless access to all its features without needing to take any further action. Utilizing advanced FIDO2 security technology, MagicEndpoint continuously authenticates the unique combination of the user and their device. This endpoint equips the IdP server with real-time insights to analyze the user’s behavior, device status, and even their intentions. Such ongoing verification enhances a zero-trust architecture while minimizing any inconvenience to the user. Transition your users away from cumbersome remote authentication processes today and elevate your security measures with MagicEndpoint's passwordless solution, ensuring peace of mind for both users and administrators alike.

If your current mobile security setup lacks the capability to address the most recent sophisticated threats that can jailbreak or root your device, you may find yourself in a precarious situation. Disturbingly, a significant number of available solutions fall short in effectively countering these advanced threats. To establish robust mobile security, it is essential to adopt a containerization strategy that not only isolates and encrypts the data accessed and stored on your device but also circumvents dependence on the Keystore for managing cryptographic keys. Prior to committing to any mobile security solution, it is vital to scrutinize potential vendors using a comprehensive checklist of mobile security requirements. To start, confirm that your device's data is fully encrypted and that any exchanged data is safeguarded with AES 256-bit encryption or a stronger alternative. Furthermore, your security protocol should ensure that work-related emails, files, and applications are containerized and encrypted separately from personal data. It is equally important to facilitate encrypted data transfers between applications on the device. Lastly, verify that the KeyStore is not utilized for the storage of cryptographic keys under any circumstances. By implementing this thorough approach, you will greatly strengthen your mobile security measures and better protect your sensitive information. Ultimately, prioritizing these requirements is essential for maintaining the integrity and confidentiality of your data in an increasingly complex threat landscape.

Implementing a robust security program with Zip is straightforward, requiring no advanced expertise, and offers the convenience of one-click workflows for essential tasks like account recovery and the deployment of CrowdStrike. We provide all the essential resources needed for you to act promptly, ensuring compliance standards are consistently met. Monitor your system’s devices, identities, and third-party applications from a comprehensive viewpoint, enabling you to modify each performance indicator as needed. Our platform effortlessly integrates leading security solutions such as CrowdStrike, Jamf, and Intune, forming a scalable security framework that is controlled via a single interface. You can create consistent security policies across Windows and macOS devices without dealing with the challenges of platform-specific setups. Zip acts as your all-encompassing partner in sourcing, deploying, configuring, and managing your enterprise security strategy. We handle all software procurement necessary to meet your clients' expectations, insurance mandates, and compliance needs, allowing you to concentrate on the core aspects of your business—its growth. With Zip, you gain exceptional peace of mind, knowing that your security program is being expertly managed and continually optimized for your organizational needs. This means you can focus on innovation while we ensure your defenses remain strong.

Leverage the Rotate cloud security platform to strengthen any organization through its adaptable hubs and seamless integrations designed to enhance security capabilities. Deepen your awareness of cyber threats and improve response efforts by identifying alerts across all hubs, interconnecting them, and prioritizing incidents based on their risk levels. With Rotate’s XDR, you can effectively integrate, consolidate, and manage all hubs efficiently. Utilize your multi-tenancy control center for performing vulnerability assessments and implementing rapid deployments. Oversee an unlimited number of clients from a single dashboard, simplifying management processes. Provide your business clients with a strong cybersecurity infrastructure while reducing potential risks in your portfolio. Rotate protects a diverse range of organizations in today’s digital landscape. Achieve comprehensive cybersecurity for every employee who accesses email or uses devices in a work environment. Although cyber insurance is a vital factor for any company confronting cyber threats, obtaining coverage can often be expensive. The extensive protection that Rotate delivers can significantly reduce overall insurance costs, enabling businesses to concentrate on growth and innovation. This all-encompassing strategy not only fortifies security but also cultivates trust with clients and partners while ensuring a safer operational environment. Ultimately, organizations can thrive in an increasingly complex digital landscape with the right security measures in place.

A groundbreaking management and security solution tailored to meet your current demands while aiding your cloud transition has now been introduced. This all-encompassing management approach is crafted to ensure both security and efficiency. By implementing a thorough management system that integrates the functionalities, data, and sophisticated intelligent features of Microsoft Intune and Microsoft System Center Configuration Manager, you can optimize your operations. Experience uninterrupted connectivity with Microsoft's cloud-based security protocols, which include conditional access driven by risk assessments for applications and sensitive data. Utilize analytics to uncover insights and address any issues that could impact user experience. Boost productivity and collaboration by offering an intuitive environment that aligns with user expectations. Equip your IT team with the tools necessary to manage various scenarios for both personal devices and corporate assets. Accelerate the benefits of your investment with swift deployment of services and hardware through seamless integration across our offerings. Strive to minimize disruptions for IT, users, and operational processes while enhancing security and maximizing your return on investment. Additionally, this innovative solution guarantees that your organization remains adaptive and competitive in an ever-evolving digital ecosystem, ensuring your long-term success.