List of the Top 25 Endpoint Protection Software for Microsoft 365 in 2026

Guardz is the unified cybersecurity platform built for MSPs. We consolidate the essential security controls, including identities, endpoints, email, awareness, and more, into one AI-native framework designed for operational efficiency. With an identity-centric approach, an elite threat hunting team, and 24/7 AI + human-led MDR, Guardz transforms cybersecurity from reactive defense into proactive protection.

Iru AI is a next-generation, AI-native security and compliance platform designed to unify and automate enterprise protection in an increasingly complex digital landscape. Built from the ground up for the AI era, Iru integrates identity management, endpoint protection, and compliance automation within a single, context-aware system. Its proprietary Iru Context Model continuously interprets relationships between users, apps, and devices, enabling intelligent actions across authentication, threat detection, and audit workflows. The Identity module eliminates passwords with device-bound authentication, ensuring frictionless yet secure access to every enterprise app. The Endpoint suite consolidates management, detection, and vulnerability response into one lightweight agent, providing real-time visibility and cross-platform consistency. Meanwhile, the Compliance engine automates control mapping and evidence collection, reducing audit preparation time while maintaining continuous readiness. Unlike fragmented legacy tools, Iru’s unified approach minimizes security gaps, streamlines administration, and improves user experience across the organization. The platform’s scalability and AI automation have helped firms cut IT workloads in half while achieving stronger security postures and regulatory compliance. Trusted by global innovators like Airbus, Notion, McLaren, and BetterHelp, Iru is transforming how enterprises secure their digital ecosystems. With over 5,000 customers and top-tier ratings for usability and innovation, Iru empowers teams to focus on strategic growth rather than operational complexity.

Eliminate the hassle of handling multiple tools for managing identity, access, devices, and inventory. Rippling consolidates everything into a single, cohesive platform—intimately connected and fueled by comprehensive employee information. Streamline tedious manual processes such as device configuration, access granting, endpoint oversight, and offboarding with just a few clicks. Gain thorough insights into users and hardware, proactively address security vulnerabilities before they turn into threats, all without the necessity of expanding your workforce. Experience the quickest route to scalable, secure IT operations—free from tool clutter and excessive costs.

Syncro serves as a comprehensive business platform designed specifically for managing a successful managed service provider (MSP). Experience the convenience of PSA, RMM, and remote access all bundled into one cost-effective solution. Additionally, you can enhance your productivity even further with seamless integrations to over 50 MSP and business applications that you already utilize. The pricing structure of Syncro is straightforward, offering a single flat fee that covers all PSA, RMM, and remote access functionalities, allowing for unlimited endpoints with no binding contracts or minimum requirements. This simplicity makes it easier for MSPs to budget and plan their services effectively.

Streamline the complete patching process using Patch Manager Plus to ensure that all production environments remain up-to-date. This versatile tool is offered in both cloud-based and on-premise formats. It includes functionalities like automated scheduling for patch deployments, detection of missing patches, testing for approval, tracking patches, ensuring compliance, and generating reports. Additionally, Patch Manager Plus enables users to produce comprehensive audit and compliance reports, enhancing oversight and management capabilities. By utilizing this software, businesses can significantly reduce downtime and improve their overall IT security posture.

Electric is revolutionizing business IT management by offering real-time support to over 30,000 users and centralized IT solutions for more than 600 clients. As a result, companies can achieve up to 50% reduction in IT expenses while ensuring consistent security measures across all devices, applications, and networks. This innovative approach not only enhances operational efficiency but also simplifies the complexities of IT management for businesses of all sizes.

ConnectWise Cybersecurity Management, which was previously known as ConnectWise Fortify, provides software and support services that enable Managed Service Providers (MSPs) to safeguard their clients' essential business assets. By offering round-the-clock threat detection, incident response, and tools for security risk assessments, these solutions simplify the process of creating a cybersecurity framework powered by MSPs, while also reducing the expenses related to continuous monitoring and support personnel. Consequently, MSPs can focus more on their core services without the added burden of cybersecurity complexities.

KACE serves as an all-in-one endpoint management solution that provides centralized control over IT systems throughout the organization. It is designed to streamline the entire process from the initial setup to continuous upkeep, effectively addressing all endpoint security and deployment requirements. By utilizing a unified inventory database, KACE enables businesses to swiftly deploy, oversee, and manage their devices, which significantly enhances device security through immediate hardware and software identification, patch management, compliance tracking, and real-time monitoring of mobile endpoints. Furthermore, KACE simplifies the complexities of maintaining device security and compliance, allowing organizations to focus on their core activities without worrying about endpoint vulnerabilities.

Around the globe, small and medium-sized enterprises (SMEs) can achieve unparalleled freedom of choice by collaborating with JumpCloud. By utilizing its cloud-based open directory platform, JumpCloud streamlines the management and security of identities, access, and devices, allowing IT teams and managed service providers (MSPs) to efficiently support a variety of operating systems including Windows, Mac, Linux, and Android. This innovative solution enables users to manage identities either directly or through their chosen HRIS or productivity tools, while also granting access to numerous on-premises and cloud applications with a single, secure set of credentials. To explore the full potential of this comprehensive platform, consider starting a free 30-day trial of JumpCloud today and experience the benefits firsthand. Embrace the future of IT management and watch your business thrive.

WithSecure's modular Elements Cloud cyber security platform seamlessly integrates Extended Detection and Response (XDR), Exposure Management and Co-Security Services into a single unified solution. WithSecure Elements Extended Detection and Response (XDR) is designed to protect modern IT estates. It minimizes the impact of attacks by using automated and advanced preventative controls that keep incident volumes and lower-level attacks at bay. AI-powered tooling enables fast detection, investigation, and response to threats across endpoints, identities, emails and other cloud-based collaboration services. Organizations can easily gain access to WithSecure expertise to get help with complex detections or widespread major incidents. WithSecure Elements XDR includes Elements Endpoint Security (your EPP+EDR), Identity Security for Microsoft Entra ID, Collaboration Protection for Microsoft 365, and Cloud Security for Azure as modules. You can flexibly choose which capabilities to include in your Elements XDR solution. WithSecure Elements Exposure Management (XM) is a continuous and proactive solution that predicts and prevents breaches against your company’s assets and business operations. Elements XM provides visibility into your attack surface and enables the efficient remediation of its highest-impact exposures through a unified view, thanks to our exposure scoring and AI-enabled recommendations. Get one solution for 360° digital exposure management and visibility across your external attack surface and internal security posture, to proactively prevent cyber-attacks. Through our flexible Elements modules made of cutting-edge software and high-quality services, customers can find the optimal solution for their needs. Together, the modules offer end-to-end business and cloud coverage. In today's unpredictable, ever-changing business environment, our all-in-one security platform helps you build and maintain a resilient business.

Take control of your cyber threats effectively by using Defense.com, which allows you to identify, prioritize, and monitor all your security risks within a single, streamlined platform. Streamline your cyber threat management with integrated features that cover detection, protection, remediation, and compliance, all within one convenient hub. By utilizing automatically prioritized and tracked threats, you can make informed decisions that bolster your overall defense strategy. Enhance your security posture through proven remediation techniques tailored to each identified risk. When faced with challenges, you can count on the expertise of experienced cyber and compliance consultants who are ready to assist you. Leverage user-friendly tools that integrate smoothly with your existing security investments, reinforcing your cyber defenses further. Gain real-time insights from penetration tests, vulnerability assessments, threat intelligence, and additional resources, all showcased on a central dashboard that emphasizes your specific risks and their severity levels. Each identified threat comes with actionable remediation advice, making it easier to implement effective security improvements. Moreover, your unique attack surface is aligned with powerful threat intelligence feeds, ensuring you remain proactive in the constantly changing realm of cybersecurity. This holistic approach not only addresses current threats but also equips you to foresee and tackle future challenges within your security framework, thereby fostering a proactive security culture. With a focus on continuous improvement and adaptation, you can maintain a resilient defense against emerging cyber threats.

ESET PROTECT Elite is an advanced cybersecurity solution tailored for enterprises, effectively merging extensive detection and response features with a solid multilayered defense architecture. By employing innovative methods such as adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis, it proficiently tackles zero-day vulnerabilities and ransomware threats. This platform offers contemporary endpoint protection for both desktop and mobile devices, alongside server security that guarantees real-time safety of data and mobile threat defenses. Furthermore, it includes full disk encryption, assisting organizations in achieving compliance with data protection regulations. ESET PROTECT Elite also features robust email security capabilities, which provide protection against phishing, malware, and spam, while safeguarding cloud applications such as Microsoft 365 and Google Workspace. With its automated vulnerability management and patching abilities, the solution streamlines the detection and rectification of security weaknesses across all endpoints, encouraging a proactive stance towards cybersecurity. In conclusion, ESET PROTECT Elite stands out as a holistic solution that effectively meets the complex and ever-changing demands posed by contemporary cybersecurity threats, ensuring that organizations remain secure in a digital landscape fraught with risks.

Microsoft Defender for Business is a comprehensive device security solution designed to help small and medium-sized businesses strengthen their cybersecurity posture. It leverages AI-powered technology to protect against ransomware, malware, phishing attacks, and other advanced threats. The solution supports a wide range of devices, including Windows, macOS, iOS, and Android, ensuring unified protection across hybrid workforces. Defender for Business includes vulnerability management tools that identify risky software and configuration gaps. Its next-generation antivirus continuously blocks known and emerging threats. AI-driven endpoint detection and response automatically disrupts attacks in real time, minimizing damage. Automated investigation and remediation streamline incident response by resolving many threats without manual effort. Simplified onboarding and management make the platform accessible even for teams without dedicated security staff. Monthly security summaries help organizations track risks and improvements. Server protection is available as an add-on for expanded coverage. Defender for Business can be used standalone or as part of Microsoft 365 Business Premium. Overall, it provides scalable, enterprise-grade security tailored to growing businesses.

The landscape of security has shifted from a simple binary of threats to a more intricate environment where pinpointing harmful entities has become increasingly difficult. In the current climate, depending solely on conventional signature-based antivirus programs is insufficient, especially for combating ransomware and new threats that frequently slip through the cracks. Although next-generation technologies are capable of addressing some vulnerabilities, they do not provide a one-size-fits-all solution, and the use of multiple anti-malware applications on a single device can lead to a fragmented system that struggles to operate cohesively. Compounding this issue, employees are accessing corporate information from a variety of devices and locations, including diverse cloud platforms. Consequently, it is crucial to implement endpoint security that is not only intelligent and streamlined but also integrated, sourced from a trusted vendor. Trend Micro™ OfficeScan™ employs advanced machine learning alongside various threat protection techniques to bridge security gaps across all user interactions and endpoints, thereby ensuring a strong defense against today's sophisticated cyber threats. This holistic strategy not only fortifies security measures but also simplifies the management process for IT teams dealing with the complexities of the modern threat landscape, ultimately leading to a more resilient organizational infrastructure.

Enterprise servers function as central nodes for data exchange, which inherently makes them vulnerable to various threats. Even within a supposedly secure network, it is possible for users or applications without adequate safeguards to unintentionally upload infected files to the server, potentially spreading these threats to other connected systems that access such files. Additionally, expansive organizations may manage hundreds or even thousands of servers, all of which require regular monitoring, configuration adjustments, and maintenance to ensure optimal performance. Today's sophisticated cyber threats can exploit numerous entry points within a network, often leaving behind concealed damage that raises the possibility of reinfection. To combat these challenges, Trend Micro™ ServerProtect™ provides comprehensive protection against a range of threats including viruses, spyware, and rootkits, while also improving the effectiveness of server security operations. This software not only offers real-time malware scanning and detection but also features tools for cleaning and repairing any compromised systems. By simplifying these security processes, ServerProtect enables organizations to sustain a higher security standard while reducing the likelihood of operational interruptions. Ultimately, the integration of such protective measures is vital for safeguarding sensitive data and maintaining business continuity in a digital landscape fraught with risks.

Effective data protection that remains uncompromised provides the flexibility needed to cater to your unique needs. Among the various data loss prevention (DLP) solutions, Digital Guardian distinguishes itself with its ability to apply either a use case-based approach—which targets specific data types or user groups—or a data risk discovery technique that uncovers previously unidentified use cases. By leveraging this risk discovery approach, organizations can gain improved insight into where sensitive data resides, how it travels within the company, and what vulnerabilities may exist, all without the requirement of setting up formal policies. Built on AWS, Digital Guardian simplifies the deployment process while keeping overhead low and scalability high, thereby enhancing the value of your security investments. It offers extensive compatibility with Windows, macOS, and Linux operating systems, as well as support for both browser-based and native applications. Additionally, its innovative “unknown risk” strategy sheds light on the location and movement of sensitive data, revealing associated risks without depending on established policies. Digital Guardian is unique in delivering a cohesive methodology for data discovery and classification, factoring in content, user, and context to ensure robust protection throughout your digital environment. This comprehensive strategy not only boosts data security but also aids in streamlining compliance efforts across varied regulatory frameworks, making it an essential tool for organizations aiming to safeguard their critical information assets. Ultimately, the adaptability and depth of Digital Guardian's solutions make it a formidable ally in navigating the complexities of data protection and compliance.

Arctic Wolf is a comprehensive cybersecurity platform built to deliver AI-driven protection and end-to-end security operations for organizations of all sizes. It combines advanced technology, continuous monitoring, and expert-led services to help businesses prevent, detect, and respond to cyber threats in real time. At the center of its ecosystem is the Aurora Platform, an open XDR solution that integrates security data from across endpoints, networks, and cloud environments into a single unified view. This allows organizations to gain full visibility into their security posture and respond quickly to emerging threats. Arctic Wolf enhances its platform with a concierge delivery model, providing dedicated security experts who guide organizations through threat detection, incident response, and risk management. The platform supports a wide range of security solutions, including managed detection and response, cloud security posture management, security awareness training, and vulnerability management. It also focuses on reducing cyber risk by combining proactive threat prevention with rapid incident response capabilities. Arctic Wolf’s ecosystem includes hundreds of integrations and partnerships, enabling seamless connectivity with existing tools and workflows. Additionally, the platform offers risk transfer and insurability support, helping organizations prepare for and mitigate the financial impact of cyber incidents. By combining AI, automation, and human expertise, Arctic Wolf enables businesses to move beyond reactive security and adopt a proactive, resilience-focused approach. It is designed to scale with evolving threats and organizational needs, ensuring long-term protection. Overall, Arctic Wolf helps organizations achieve stronger security outcomes, reduce risk, and maintain confidence in their digital operations.

As cyber threats increasingly evolve and proliferate through new security channels, the level of complexity, expertise, and resources necessary to combat these dangers is also rising significantly. This mounting complexity often leads security teams to feel inundated and challenged in their efforts to stay ahead. For more than twenty years, SilverSky has evolved as a managed security service provider, addressing the security and regulatory needs of small and mid-sized enterprises with clear and cost-effective solutions. Our primary focus is to assist industries that face rigorous regulatory scrutiny. Relying exclusively on perimeter firewalls for monitoring is no longer sufficient; organizations must now manage every point of interaction within their networks. This extensive surveillance includes networks, servers, databases, personnel, and endpoints. A professional Security Operations Center, or SOC as a service, is the most reliable approach to achieve this level of oversight. SilverSky Security Monitoring is committed to managing both perimeter and core security devices, ensuring that businesses not only fulfill but surpass regulatory compliance requirements while bolstering their overall security strength. Our dedication to excellence drives us to continually refine our strategies, enabling us to stay one step ahead of emerging threats and challenges in the cybersecurity landscape. By doing so, we empower our clients to focus on their core business functions with peace of mind.

The Symantec Integrated Cyber Defense (ICD) Platform delivers an extensive array of security offerings, encompassing Endpoint Security, Identity Security, Information Security, and Network Security, to effectively protect both on-premises and cloud environments. As a trailblazer in merging and coordinating security capabilities across various systems, Symantec enables organizations to embrace cloud solutions at their own pace while safeguarding previous investments in essential infrastructure. Recognizing that many organizations rely on a variety of vendors, Symantec introduced the Integrated Cyber Defense Exchange (ICDx), which promotes the smooth integration of third-party solutions and fosters intelligence sharing across the platform. Distinctive in the realm of cyber defense, Symantec's solutions are designed to support all infrastructure types, whether they are entirely on-premises, exclusively cloud-based, or a combination of both, ensuring that every enterprise can achieve adaptable protection tailored to its needs. This emphasis on flexibility and integration not only enhances security but also reinforces Symantec’s status as a leading figure in the comprehensive cyber defense arena. By prioritizing a user-centric approach, Symantec continues to innovate and evolve, shaping the future of cybersecurity for organizations around the globe.

Maintaining the security of endpoint devices is essential for any organization. Those operating in high-risk environments can particularly benefit from specialized products and services designed to enhance their security posture. These advanced solutions are specifically developed for various types of devices, including desktops, laptops, and thin clients. Their foundations are backed by extensive research and government support, which ensures their effectiveness. The offerings encompass a wide array of managed services, continuous security monitoring, and dedicated research and development efforts. The adoption of zero trust architectures plays a critical role in bolstering the security of cloud services by integrating assessments of both device health and user identity for access control. Furthermore, permitting access to corporate resources from unmanaged endpoints can seriously threaten the integrity of the supply chain. By prioritizing both device health and identity verification, organizations can significantly reduce the risks associated with third-party IT interactions. In addition, managed services facilitate the establishment of secure cloud and mobile infrastructures, promoting safer collaboration with external partners. It is imperative that organizations implement robust security measures to safeguard sensitive data and ensure the continuity of their operations. This proactive approach not only enhances security but also builds trust among stakeholders.

The threats faced by an organization's infrastructure have become increasingly aggressive, encompassing a wide range of issues from malware and advanced persistent threats (APTs) to extortion attempts and internal security breaches. In today's business environment, it is crucial to consider the rapid growth of smartphones, tablets, and the consumerization of IT, along with the challenges posed by remote workers, contractors, partners, and essential services hosted in the cloud. As a result, the necessity for robust security protocols has intensified, making them more complex than ever before. To effectively protect your data and systems, it is vital to implement a flexible, multi-layered defense strategy that encompasses every facet of your IT landscape, including the network, perimeter, data, applications, and endpoints, while also identifying and managing vulnerabilities that could potentially place your organization at risk. Activereach provides an extensive array of network security solutions aimed at defending your business against emerging threats, optimizing network performance, and boosting operational efficiencies, all of which contribute to a more secure and resilient infrastructure. Moreover, as the digital landscape keeps changing, maintaining a proactive approach to security is essential not only for immediate protection but also for ensuring long-term organizational success and stability.

MagicEndpoint delivers unparalleled user authentication security while ensuring an exceptional user experience. After the initial unlocking of the endpoint, users gain seamless access to all its features without needing to take any further action. Utilizing advanced FIDO2 security technology, MagicEndpoint continuously authenticates the unique combination of the user and their device. This endpoint equips the IdP server with real-time insights to analyze the user’s behavior, device status, and even their intentions. Such ongoing verification enhances a zero-trust architecture while minimizing any inconvenience to the user. Transition your users away from cumbersome remote authentication processes today and elevate your security measures with MagicEndpoint's passwordless solution, ensuring peace of mind for both users and administrators alike.

If your current mobile security setup lacks the capability to address the most recent sophisticated threats that can jailbreak or root your device, you may find yourself in a precarious situation. Disturbingly, a significant number of available solutions fall short in effectively countering these advanced threats. To establish robust mobile security, it is essential to adopt a containerization strategy that not only isolates and encrypts the data accessed and stored on your device but also circumvents dependence on the Keystore for managing cryptographic keys. Prior to committing to any mobile security solution, it is vital to scrutinize potential vendors using a comprehensive checklist of mobile security requirements. To start, confirm that your device's data is fully encrypted and that any exchanged data is safeguarded with AES 256-bit encryption or a stronger alternative. Furthermore, your security protocol should ensure that work-related emails, files, and applications are containerized and encrypted separately from personal data. It is equally important to facilitate encrypted data transfers between applications on the device. Lastly, verify that the KeyStore is not utilized for the storage of cryptographic keys under any circumstances. By implementing this thorough approach, you will greatly strengthen your mobile security measures and better protect your sensitive information. Ultimately, prioritizing these requirements is essential for maintaining the integrity and confidentiality of your data in an increasingly complex threat landscape.

Implementing a robust security program with Zip is straightforward, requiring no advanced expertise, and offers the convenience of one-click workflows for essential tasks like account recovery and the deployment of CrowdStrike. We provide all the essential resources needed for you to act promptly, ensuring compliance standards are consistently met. Monitor your system’s devices, identities, and third-party applications from a comprehensive viewpoint, enabling you to modify each performance indicator as needed. Our platform effortlessly integrates leading security solutions such as CrowdStrike, Jamf, and Intune, forming a scalable security framework that is controlled via a single interface. You can create consistent security policies across Windows and macOS devices without dealing with the challenges of platform-specific setups. Zip acts as your all-encompassing partner in sourcing, deploying, configuring, and managing your enterprise security strategy. We handle all software procurement necessary to meet your clients' expectations, insurance mandates, and compliance needs, allowing you to concentrate on the core aspects of your business—its growth. With Zip, you gain exceptional peace of mind, knowing that your security program is being expertly managed and continually optimized for your organizational needs. This means you can focus on innovation while we ensure your defenses remain strong.

Leverage the Rotate cloud security platform to strengthen any organization through its adaptable hubs and seamless integrations designed to enhance security capabilities. Deepen your awareness of cyber threats and improve response efforts by identifying alerts across all hubs, interconnecting them, and prioritizing incidents based on their risk levels. With Rotate’s XDR, you can effectively integrate, consolidate, and manage all hubs efficiently. Utilize your multi-tenancy control center for performing vulnerability assessments and implementing rapid deployments. Oversee an unlimited number of clients from a single dashboard, simplifying management processes. Provide your business clients with a strong cybersecurity infrastructure while reducing potential risks in your portfolio. Rotate protects a diverse range of organizations in today’s digital landscape. Achieve comprehensive cybersecurity for every employee who accesses email or uses devices in a work environment. Although cyber insurance is a vital factor for any company confronting cyber threats, obtaining coverage can often be expensive. The extensive protection that Rotate delivers can significantly reduce overall insurance costs, enabling businesses to concentrate on growth and innovation. This all-encompassing strategy not only fortifies security but also cultivates trust with clients and partners while ensuring a safer operational environment. Ultimately, organizations can thrive in an increasingly complex digital landscape with the right security measures in place.