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What is ESMFold2?

Building upon its predecessor, ESMFold, ESMFold2 sets a new standard in the realm of single-sequence structure prediction while also enabling the design of novel functional proteins by delving into the latent space of the ESMC model. This sophisticated model can accurately predict high-resolution, all-atom 3D structures of biomolecular complexes directly from amino acid sequences and incorporates multiple sequence alignments to enhance accuracy for challenging targets. Designed to predict structures using both sequence and structural modalities, it utilizes ESM representations that power a sequence of looped folding layers, while a diffusion model converts pairwise representations into atomic-resolution results. ESMFold2 stands out in its ability to forecast protein structures from amino acid sequences, providing comprehensive structural information, including exact all-atom coordinates for backbone and side chains, as well as confidence metrics and optional distogram predictions for thorough structural analysis. In addition, its groundbreaking methodology deepens the understanding of protein folding dynamics and their functional implications, positioning it as an indispensable tool for researchers engaging in this area of study. Ultimately, ESMFold2 not only advances structural biology but also opens new avenues for the development of protein-based applications.

What is COLUMBO?

A universal multivariable optimizer, designed for closed-loop systems, aims to improve the performance and quality of Model Predictive Control (MPC) systems. This optimizer harnesses data from Excel files derived from Dynamic Matrix Control (DMC) by Aspen Tech, Robust Model Predictive Control Technology (RMPCT) from Honeywell, or Predict Pro from Emerson, facilitating the development and fine-tuning of precise models for various multivariable-controller variable (MV-CV) pairs. This cutting-edge optimization solution does away with the need for step tests that are usually required by Aspen Tech and Honeywell, functioning entirely in the time domain to maintain user-friendliness, compactness, and efficiency. As Model Predictive Controls (MPC) often involve numerous dynamic models—sometimes tens or even hundreds—there is a significant risk of utilizing incorrect models. Inaccurate dynamic models in MPCs can introduce bias, which appears as model prediction errors, leading to inconsistencies between expected signals and actual sensor measurements. COLUMBO emerges as a robust tool to bolster the precision of Model Predictive Control (MPC) models, effectively leveraging either open-loop or fully closed-loop data to guarantee peak performance. By tackling the risks associated with errors in dynamic models, COLUMBO not only enhances the reliability of the control system but also contributes to a more efficient operational framework. Ultimately, its implementation is expected to yield substantial advancements in control system effectiveness across various applications.

Media

Media

Integrations Supported

Biohub
Mira
Python

Integrations Supported

Aspen DMC3
Microsoft Excel

API Availability

Has API

API Availability

Pricing Information

Free
Free Version

Pricing Information

Pricing not provided
Free Trial Offered?

Supported Platforms

SaaS

Supported Platforms

SaaS

Customer Service / Support

Web-Based Support

Customer Service / Support

Standard Support
Web-Based Support

Training Options

Documentation Hub

Training Options

Documentation Hub
Online Training
On-Site Training

Company Facts

Organization Name

Biohub

Date Founded

2016

Company Location

United States

Company Website

biohub.ai/models/esmfold2

Company Facts

Organization Name

PiControl Solutions

Company Location

United States

Company Website

www.picontrolsolutions.com/products/columbo/

Categories and Features

AI Models

Not specified

AI Science

Not specified

Categories and Features

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