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What is Folklore Clinical Variant Interpretation?

Helena Bioinformatics develops Folklore as its flagship platform for professional review of genomic variants. Laboratories and research teams can examine classification, supporting scientific evidence, phenotype, inheritance and prioritisation together in a traceable case. Supported work includes panels, exomes and genomes, with framework-specific handling of nuclear, mitochondrial and structural or copy-number variants. Folklore also offers a separate public MCP interface for read-only evidence and literature discovery. This interface does not accept patient data or private case files. Folklore is research-use-only and not CE-marked. A qualified specialist remains responsible for final interpretation; the product does not diagnose or recommend treatment.

What is AlphaGenome?

AlphaGenome is an innovative API and Python toolkit crafted by Google DeepMind, specifically tailored for the realm of computational genomics. This powerful tool allows researchers to input DNA sequences or genetic variants to gain insights into various aspects such as gene expression, RNA splicing, chromatin accessibility, transcription-factor interactions, histone modifications, and genomic interactions. Additionally, it offers variant scoring and aids in the examination of genomic regions across both human and mouse datasets, enriched with tutorials and reference materials to support the development of programmatic workflows. By utilizing this resource, researchers can delve into how genetic changes impact gene regulation and effectively prioritize hypotheses for further exploration. Access is provided through a hosted API, along with a Python package for implementation on local systems, and numerous notebook examples to facilitate practical use. Although AlphaGenome proves to be a significant asset for research endeavors, it is crucial to understand that it has not undergone validation for clinical or diagnostic use, and its predictions should not be interpreted as clinical results. Furthermore, the platform fosters collaboration among scientists by creating an interactive environment that enhances data analysis, encouraging the sharing of insights and findings within the research community.

Media

Media

Integrations Supported

Integrations Supported

Google Antigravity
Google Cloud Platform
Google Colab

API Availability

Has API

API Availability

Has API

Pricing Information

Pricing not provided

Pricing Information

Free for non-commercial research use, subject to terms. Commercial research access is in private preview; commercial and enterprise workflows are also offered through Google Cloud.
Free Version

Supported Platforms

SaaS

Supported Platforms

SaaS

Customer Service / Support

Web-Based Support

Customer Service / Support

Web-Based Support

Training Options

Documentation Hub

Training Options

Documentation Hub

Company Facts

Organization Name

Helena Bioinformatics

Company Location

Bulgaria

Company Website

folklore.helena.bio

Company Facts

Organization Name

Google DeepMind

Date Founded

2010

Company Location

United Kingdom

Company Website

deepmind.google/science/alphagenome/

Categories and Features

Categories and Features

Bioinformatics

Not specified

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