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What is Swiss-PdbViewer?

Swiss-PdbViewer, often referred to as DeepView, is a user-friendly software application designed for the concurrent analysis of multiple proteins. It allows users to align these proteins to assess structural similarities and inspect essential elements, including active sites. The software streamlines the acquisition of data regarding amino acid substitutions, hydrogen bonds, angles, and atomic distances via its straightforward graphical interface and menu options. Created by Nicolas Guex in 1994, Swiss-PdbViewer was initially designed to work closely with SWISS-MODEL, an automated homology modeling server established by the Swiss Institute of Bioinformatics (SIB) within the Structural Bioinformatics Group at the Biozentrum in Basel. As SWISS-MODEL's web interface has evolved over the years, enhancing its functionality for sophisticated modeling tasks, the need for a direct link to Swiss-PdbViewer has diminished, resulting in the cessation of its support. This shift illustrates the ongoing advancements in bioinformatics tools and the increasing complexity of their features. Consequently, users now enjoy a broader array of capabilities that reflect the rapidly changing landscape of protein modeling and analysis.

What is ESMFold2?

Building upon its predecessor, ESMFold, ESMFold2 sets a new standard in the realm of single-sequence structure prediction while also enabling the design of novel functional proteins by delving into the latent space of the ESMC model. This sophisticated model can accurately predict high-resolution, all-atom 3D structures of biomolecular complexes directly from amino acid sequences and incorporates multiple sequence alignments to enhance accuracy for challenging targets. Designed to predict structures using both sequence and structural modalities, it utilizes ESM representations that power a sequence of looped folding layers, while a diffusion model converts pairwise representations into atomic-resolution results. ESMFold2 stands out in its ability to forecast protein structures from amino acid sequences, providing comprehensive structural information, including exact all-atom coordinates for backbone and side chains, as well as confidence metrics and optional distogram predictions for thorough structural analysis. In addition, its groundbreaking methodology deepens the understanding of protein folding dynamics and their functional implications, positioning it as an indispensable tool for researchers engaging in this area of study. Ultimately, ESMFold2 not only advances structural biology but also opens new avenues for the development of protein-based applications.

Media

Media

Integrations Supported

Biohub
Python

Integrations Supported

Biohub
Python

API Availability

Has API

API Availability

Has API

Pricing Information

Pricing not provided.
Free Trial Offered?
Free Version

Pricing Information

Free
Free Trial Offered?
Free Version

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Supported Platforms

SaaS
Android
iPhone
iPad
Windows
Mac
On-Prem
Chromebook
Linux

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Customer Service / Support

Standard Support
24 Hour Support
Web-Based Support

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Training Options

Documentation Hub
Webinars
Online Training
On-Site Training

Company Facts

Organization Name

Swiss-PdbViewer

Date Founded

1994

Company Location

Switzerland

Company Website

spdbv.unil.ch/

Company Facts

Organization Name

Biohub

Date Founded

2016

Company Location

United States

Company Website

biohub.ai/models/esmfold2

Categories and Features

Categories and Features

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